Functional polymorphism of the NFKB1 gene promoter is not relevant in predisposition to celiac disease

Scandinavian Journal of Gastroenterology
B RuedaJavier Martin

Abstract

The nuclear factor (NF)-kappaB is one of the pivotal regulators of autoimmunity and inflammation, which has been shown to be activated in the inflamed mucosa of patients with celiac disease (CD). Recently, in the NFKB1 gene promoter region, a common insertion/deletion (-94ins/delATTG) polymorphism located between two putative key promoter regulatory elements was described. The aim of this study was to investigate the contribution of the -94ins/delATTG NFKB1 gene promoter functional variant to CD genetic predisposition. A case-control cohort comprising 478 patients with CD and 711 healthy controls as well as a panel of 196 celiac families was genotyped for the 94ins/delATTG NFKB1 polymorphism, using a polymerase chain reaction (PCR) method combined with fluorescence technology. We found no statistically significant differences between CD patients and controls when the -94ins/delATTG genotype and allele distributions were compared. Accordingly, the familial analysis did not reach statistically significant deviation in the transmission of -94ins/delATTG alleles to the affected offspring. From these results, it could be suggested that the -94ins/delATTG NFKB1 polymorphism does not play a major role in CD susceptibility.

References

Jun 3, 2000·Annual Review of Immunology·L M Sollid
Feb 28, 2002·American Journal of Epidemiology·W James Gauderman
May 16, 2002·Journal of Medical Genetics·S PopatR S Houlston
Sep 5, 2002·Nature Reviews. Immunology·Ludvig M Sollid
Apr 16, 2003·Tissue Antigens·A S Louka, L M Sollid
May 14, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Maria Chiara MaiuriRosa Carnuccio
Jul 8, 2003·Naunyn-Schmiedeberg's Archives of Pharmacology·Maria Chiara MaiuriRosa Carnuccio
Aug 9, 2003·Lancet·Peter H R Green, Bana Jabri
Aug 14, 2003·Genetic Epidemiology·Frank Dudbridge
May 4, 2004·Nature Reviews. Molecular Cell Biology·Lin-Feng Chen, Warner C Greene
Jun 9, 2004·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·B RuedaJ Martín
Jun 25, 2004·Genes and Immunity·B RuedaJ Martín
Oct 19, 2004·Trends in Immunology·Marios HadjivassiliouNicola Woodroofe

❮ Previous
Next ❯

Citations

Nov 7, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B ZhouL Zhang
Jun 11, 2009·Japanese Journal of Clinical Oncology·Jong Gwang KimWansik Yu
Mar 12, 2008·Archives of Dermatological Research·Hong LiYu Feng Liu
Jan 22, 2021·Expert Review of Clinical Immunology·Paolo D'AvinoAlessio Fasano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.