Abstract
The nuclear factor (NF)-kappaB is one of the pivotal regulators of autoimmunity and inflammation, which has been shown to be activated in the inflamed mucosa of patients with celiac disease (CD). Recently, in the NFKB1 gene promoter region, a common insertion/deletion (-94ins/delATTG) polymorphism located between two putative key promoter regulatory elements was described. The aim of this study was to investigate the contribution of the -94ins/delATTG NFKB1 gene promoter functional variant to CD genetic predisposition. A case-control cohort comprising 478 patients with CD and 711 healthy controls as well as a panel of 196 celiac families was genotyped for the 94ins/delATTG NFKB1 polymorphism, using a polymerase chain reaction (PCR) method combined with fluorescence technology. We found no statistically significant differences between CD patients and controls when the -94ins/delATTG genotype and allele distributions were compared. Accordingly, the familial analysis did not reach statistically significant deviation in the transmission of -94ins/delATTG alleles to the affected offspring. From these results, it could be suggested that the -94ins/delATTG NFKB1 polymorphism does not play a major role in CD susceptibility.
References
Aug 1, 1990·Archives of Disease in Childhood
Dec 29, 1995·The Journal of Biological Chemistry·K YamamotoS Yamamoto
Jun 3, 2000·Annual Review of Immunology·L M Sollid
Feb 28, 2002·American Journal of Epidemiology·W James Gauderman
May 16, 2002·Journal of Medical Genetics·S PopatR S Houlston
Sep 5, 2002·Nature Reviews. Immunology·Ludvig M Sollid
Apr 16, 2003·Tissue Antigens·A S Louka, L M Sollid
May 14, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Maria Chiara MaiuriRosa Carnuccio
Jul 8, 2003·Naunyn-Schmiedeberg's Archives of Pharmacology·Maria Chiara MaiuriRosa Carnuccio
Aug 9, 2003·Lancet·Peter H R Green, Bana Jabri
Aug 14, 2003·Genetic Epidemiology·Frank Dudbridge
Nov 14, 2003·Human Molecular Genetics·Amir S KarbanSteven R Brant
Jan 9, 2004·Genes and Immunity·K HaimilaP Holopainen
May 4, 2004·Nature Reviews. Molecular Cell Biology·Lin-Feng Chen, Warner C Greene
Jun 9, 2004·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·B RuedaJ Martín
Jun 25, 2004·Genes and Immunity·B RuedaJ Martín
Jul 13, 2004·Nature Genetics·Dehuang GuoCong-Yi Wang
Jul 29, 2004·FEBS Letters·Lenka JelínkováHelena Tlaskalová-Hogenová
Oct 19, 2004·Trends in Immunology·Marios HadjivassiliouNicola Woodroofe
Jan 22, 2005·Immunological Reviews·Jordan S OrangeRaif S Geha
Feb 17, 2005·Tissue Antigens·G OrozcoJ Martín
May 21, 2005·Inflammatory Bowel Diseases·Javier OliverJavier Martín
Citations
Mar 12, 2010·DNA and Cell Biology·Bin ZhouLin Zhang
Nov 7, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B ZhouL Zhang
Jun 11, 2009·Japanese Journal of Clinical Oncology·Jong Gwang KimWansik Yu
Jul 11, 2012·BMC Gastroenterology·Renquan LuLin Guo
Jun 2, 2009·BMC Medical Genetics·Bin ZhouLin Zhang
Feb 24, 2009·Surgery·Su-Shun LoWin-Yiu Lui
Nov 14, 2008·Cancer Letters·Bin ZhouLin Zhang
Jul 12, 2008·Clinical and Experimental Dermatology·B YalcinN Alli
Dec 16, 2010·Tissue Antigens·Y F ZouH Su
Dec 10, 2009·Anaesthesia·J F WangA D Lu
Aug 11, 2007·Genes and Immunity·A KurylowiczT Bednarczuk
Mar 12, 2008·Archives of Dermatological Research·Hong LiYu Feng Liu
Dec 20, 2014·Medicine·Tang HuaWang Jingjie
Oct 10, 2009·Autoimmunity·Ainara Castellanos-RubioJose Ramon Bilbao
Jan 22, 2021·Expert Review of Clinical Immunology·Paolo D'AvinoAlessio Fasano