Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population.

PloS One
Audrey V GrantT H Beaty

Abstract

IL-13 is a signature cytokine of the helper T cell type 2 (TH2) pathway which underlies host defense to helminthic infection and activates production of IgE in both parasitized populations and in urban settings after allergen exposure. Two functional polymorphisms in IL13, rs1800925 (or c.1-1111C>T) and rs20541 (or R130Q) were previously found to be associated with Schistosoma hematobium infection intensity. They have not been thoroughly explored in S. mansoni-endemic populations, however, and were selected along with 5 tagging SNPs for genotyping in 812 individuals in 318 nuclear families from a schistosomiasis-endemic area of Conde, Bahia, in Brazil. Regression models using GEE to account for family membership and family-based quantitative transmission disequilibrium tests (QTDT) were used to evaluate associations with total serum IgE (tIgE) levels and S. mansoni fecal egg counts adjusted for non-genetic covariates. We identified a protective effect for the T allele at rs20541 (P = 0.005) against high S. mansoni egg counts, corroborated by QTDT (P = 0.014). Our findings also suggested evidence for protective effects for the T allele at rs1800925 and A allele at rs2066960 after GEE analysis only (P = 0.050, 0.0002). The two fu...Continue Reading

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Citations

Oct 3, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·V D Mangano, D Modiano
Aug 10, 2015·Cytokine·Richard D May, Michael Fung
Sep 4, 2014·European Journal of Human Genetics : EJHG·Sayantan DasJames T Elder
Feb 13, 2017·The Journal of Allergy and Clinical Immunology·Xin LongQian Chen
Feb 15, 2019·Vaccines·John Foerster, Aleksandra Molęda
Nov 13, 2012·PloS One·Alphaxard ManjuranoChristopher Drakeley
Oct 27, 2016·Scandinavian Journal of Immunology·A L C FigueiredoC N L Morais
Mar 5, 2021·Frontiers in Immunology·Estelle M MewambaGustave Simo

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Methods Mentioned

BETA
dissection

Software Mentioned

STATA
QTDT

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