Functional polymorphisms in inbred rat strains and their allele frequencies in commercially available outbred stocks

Physiological Genomics
Takashi KuramotoTadao Serikawa

Abstract

Polymorphisms that have been proven to influence gene functions are called functional polymorphisms. It is significant to know the distribution of functional polymorphisms in the rat, widely used in animal models for human diseases. In this study, we assessed 16 functional polymorphisms consisting of 3 coat color and 13 disease-associated genes in 136 rat strains, as a part of the genetic profiling program of the National Bio Resource Project for the Rat (NBRP-Rat). Polymorphisms of Cdkn1a, Fcgr3, Grp10, Lss, and Fdft1, which were proven to function in prostate tumorigenesis, glomerulonephritis, hyperphagia, and cholesterol biosynthesis, were shared among various inbred strains. These findings indicated that most rat strains harbored the disease-associated alleles and suggested that many unidentified functional polymorphisms might exist in inbred rat strains. The functional polymorphisms shared in inbred strains were also observed within outbred stocks available commercially. Therefore, this implies that experimental plans based on either rat inbred strains or outbred stocks need to be carefully designed with a full understanding of the genetic characteristics of the animals. To select the most suitable strains for experiments,...Continue Reading

References

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Citations

Sep 10, 2014·Experimental Animals·Satoshi NakanishiTakashi Kuramoto
Aug 6, 2009·Experimental Animals·Tadao SerikawaTakashi Kuramoto
Dec 6, 2012·Physiological Genomics·Rosemarie PanettaThierry Groblewski
Dec 21, 2011·The Journal of Biological Chemistry·Theresa H PageJacques Behmoaras

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