Functional polymorphisms in the promoter region of MMP-2 and MMP-9 and susceptibility to obstructive sleep apnea

Scientific Reports
Chao CaoZaichun Deng

Abstract

Genetic susceptibility to obstructive sleep apnea (OSA) has been a research focus in the scientific community in the past few years. In this study, we recruited 375 subjects to investigate whether functional polymorphisms in the promoter region of matrix metalloproteinase (MMP)-2 (-1306C/T) and MMP-9 (-1562C/T) increased susceptibility to OSA. Our study showed no significant association between MMP-2 -1306C/T polymorphism and risk of OSA (T vs. C: OR = 1.01, 95% CI = 0.67-1.52; P = 0.97). Compared with the MMP-9 -1562C allele, the -1562T allele was associated with increased risk of OSA (T vs. C: OR = 1.56, 95% CI = 1.02-2.39; P = 0.04). However, neither MMP-2 -1306C/T nor MMP-9 -1562C/T polymorphism was found to be associated with severity of the disease. Our study suggested that the MMP-2 -1306C/T polymorphism was not associated with OSA susceptibility, whereas the MMP-9 -1562T allele was associated with increased risk of OSA.

References

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Citations

May 29, 2016·Sleep Medicine Clinics·Abdelnaby KhalyfaDavid Gozal
Jul 15, 2015·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Mustafa YalcınkayaFeride Iffet Sahin
Aug 20, 2019·Sleep & Breathing = Schlaf & Atmung·Nurhan SariogluCelalettin Cevik
Aug 27, 2021·European Journal of Clinical Investigation·Minhan YiYuan Zhang

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Methods Mentioned

BETA
transfection
genotyping
PCR

Software Mentioned

SPSS
GraphPad Prism

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