Abstract
Cyclooxygenase-2 (COX-2) is an enzyme involved in the synthesis of prostaglandins and thromboxanes, which are regulators of processes that are relevant to cancer development. It is involved in carcinogenesis, immune response suppression, apoptosis inhibition, angiogenesis, and tumor cell invasion and metastasis. The gene for COX-2, designated as prostaglandin-endoperoxide synthase 2 (PTGS-2), carries polymorphisms, such as -765G>C, 1195G>A in the promoter region, and 8473T>C in the 3'-untranslated region (UTR), which have been associated with susceptibility to malignant disease. We undertook a case-control study of 212 urothelial bladder cancer (UBC) cases and 250 controls to investigate the association between COX-2 polymorphism and bladder cancer susceptibility, using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method and also investigated gene-environment interactions. Cox-2 765G>C, a variant(C) allele carrier, was at an increased risk of UBC (odds ratio [OR] = 1.90; P = .004); however, -1195G>A; -1290A>G; and 3'UTR 8473T>C polymorphisms of COX-2 gene were not significantly associated with UBC. 765G>C also was associated with the invasive stage of a bladder tumor (OR = 2.73; P = .033). H...Continue Reading
References
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Aug 30, 1994·Biochemical and Biophysical Research Communications·R TazawaL H Wang
May 1, 1994·European Journal of Biochemistry·T KosakaT Tanabe
Aug 1, 1996·American Journal of Epidemiology·M J Khoury, W D Flanders
Dec 10, 1998·Journal of Surgical Oncology·K UefujiN Shinomiya
Jul 10, 1999·The International Journal of Biochemistry & Cell Biology·T HlaO C Trifan
Apr 11, 2001·The Journal of Biological Chemistry·S J Cok, A R Morrison
Oct 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Anastasia PapafiliGeoffrey J Laurent
Nov 15, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G Singh-Ranger, K Mokbel
May 31, 2003·Scandinavian Journal of Urology and Nephrology·Per LarssonGunnar Steineck
Feb 3, 2004·Carcinogenesis·Ramesh C K PanguluriRick A Kittles
Sep 17, 2004·The Journal of Urology·Yoichi MizutaniTsuneharu Miki
Dec 15, 2004·Cancer Letters·Sokbom KangHyo Pyo Lee
Mar 16, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Cornelia M UlrichJeannette Bigler
Mar 22, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Z HuH Shen
May 3, 2005·FEBS Letters·Joanne StocksAlan J Knox
Jul 2, 2005·The Journal of Allergy and Clinical Immunology·Marek SanakAndrew Szczeklik
Aug 9, 2005·Gastroenterology·Xuemei ZhangDongxin Lin
Nov 15, 2006·Annual Review of Medicine·Yong I Cha, Raymond N DuBois
Feb 3, 2007·Carcinogenesis·Louis W ChangPinpin Lin
Feb 14, 2007·The Journal of Urology·Rosalyn Adam
Jun 22, 2007·The American Journal of Gastroenterology·Leon M G MoonsJohannes G Kusters
Oct 31, 2007·Molecular Biology Reports·Hela Ben NasrLotfi Chouchane
Jan 1, 2008·Mutation Research·Ulla VogelAnne Tjønneland
Jan 15, 2008·Carcinogenesis·L M G MoonsP D Siersema
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos
Dec 5, 2008·Scandinavian Journal of Urology and Nephrology. Supplementum·Paolo Boffetta
Jan 13, 2009·Carcinogenesis·Alexander GreenhoughAbderrahmane Kaidi
May 12, 2009·Mutation Research·Rohit UpadhyayBalraj Mittal
Citations
Apr 12, 2014·Gene·Aml F GharibWael H Elsawy
Nov 1, 2011·World Journal of Gastroenterology : WJG·Renata Talar-WojnarowskaEwa Malecka-Panas
Mar 8, 2011·Archives of Toxicology·Klaus GolkaJan G Hengstler
Nov 1, 2011·Breast Cancer Research and Treatment·Juliana S Festa-VasconcellosRosane Vianna-Jorge
Jun 28, 2011·Pancreas·Gül ÖzhanAnn K Daly
Nov 1, 2011·Cancer Metastasis Reviews·Prasanna EkambaramKenneth V Honn
May 15, 2013·Actas urologicas españolas·J FerrísJ A Ortega
Oct 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Hedieh Moradi TabrizSudabeh Yusefnia
Jul 19, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Di WangChun-Yan Wu
Aug 25, 2012·Advances in Urology·Luís LimaLúcio Santos
Dec 7, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D N PirandaR Vianna-Jorge
Nov 23, 2011·Urologia Internationalis·Luís LimaLúcio Santos
Jul 8, 2011·Mutagenesis·Zhipeng Tang Shukui Wang
Jul 25, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Yang Chen, Jilong Liu
Aug 26, 2018·BMC Cancer·Qiuping LiTianjiang Ma
Jan 8, 2014·Oncology Letters·Célia Aparecida Marques PimentaNora Manoukian Forones
Apr 22, 2016·International Journal of Epidemiology·Frits Hm van OschMaurice P Zeegers
Jun 11, 2019·Analytical Cellular Pathology (Amsterdam)·Basim Al-MaghrabiJaudah Al-Maghrabi
Jan 7, 2014·Molecular Biology Reports·Praveen Kumar JaiswalRama Devi Mittal
Sep 12, 2014·Molecular Biology Reports·Xiao-Ling YuXiao-Ming Pan
Jan 8, 2020·Biomarkers in Cancer·Nadezda LipunovaMaurice P Zeegers
Jul 3, 2021·Cancers·Irina LarionovaJulia Kzhyshkowska