PMID: 15247627Jul 13, 2004Paper

Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis

Pharmacogenetics
M VerlaanJ P H Drenth

Abstract

Chronic pancreatitis (CP) is associated with alcohol abuse, smoking and other dietary or environmental factors. UDP-glucuronosyltransferases (UGTs) are phase II detoxifying enzymes responsible for glucuronidation of various exogenous and endogenous compounds. Genetic variations, resulting in variable rates of glucuronidation, are of toxicological and physiological importance and are frequently associated with diseases. Recently, a genetic polymorphism in UGT1A7 was possibly associated with an increased risk for CP. We investigated whether polymorphisms in the genes for UGT1A1, UGT1A6 and UGT1A8 modified the risk for CP. DNA samples were obtained from 258 adult CP patients with alcoholic (n = 153), hereditary (n = 25) or idiopathic (n = 80) origin. DNA from 140 healthy controls was analyzed for comparison. Patients and controls were all of Caucasian origin. Genetic polymorphisms in UGTs were determined by PCR, eventually followed by restriction-fragment-length-polymorphism analyses in all subjects. The distribution of the various alleles of UGT1A1, UGT1A6 and UGT1A8 did not differ between CP patients and healthy controls. These data suggest that genetic polymorphisms in UGT1A1, UGT1A6 and in UGT1A8 do not predispose to the devel...Continue Reading

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Citations

Nov 30, 2005·The Pharmacogenomics Journal·M L MaitlandA Di Rienzo
Aug 12, 2005·Current Opinion in Gastroenterology·Matthew J DiMagno, Eugene P DiMagno
Aug 14, 2012·Genetics and Molecular Biology·Xiaoqing ZhangJin Yang
Mar 2, 2006·Digestive Diseases·David C Whitcomb
Apr 22, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Gwendolyn E KuehlJeannette Bigler
Nov 1, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Gwendolyn E KuehlJohanna W Lampe

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