Functional primate genomics--leveraging the medical potential.

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Wolfgang Enard

Abstract

Within biomedicine, comparative genomics is crucial for interpreting human genetic variants and building proper animal models. As our closest relatives, primates are of particular relevance in this frame work. Here, I review principles and concrete examples of this approach. Since one can expect that generating the necessary genomic DNA sequences will not be the major limiting factor in the near future, I argue that in analogy to human biomedicine, comprehensive phenotyping of different primates will be a crucial next step to tap the full potential of comparative genomics. Especially the possibility to generate pluripotent stem cells from primates should allow extending the comparative approach to many medically relevant questions.

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Citations

May 1, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Detlev Ganten, Randolph Nesse
Mar 19, 2014·Stem Cell Research·Stephanie WunderlichWolfgang Enard
Jun 10, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Nissi M Varki, Ajit Varki
May 20, 2015·Current Biology : CB·Wolfgang Enard
Sep 15, 2014·Current Opinion in Genetics & Development·Wolfgang Enard
Jun 7, 2014·Frontiers in Human Neuroscience·Wolfgang Enard
Nov 11, 2014·Annual Review of Animal Biosciences·Jill Pecon-Slattery
Oct 8, 2016·Current Opinion in Genetics & Development·Martin KuhlwilmTomas Marques-Bonet
Oct 26, 2016·Current Biology : CB·Wolfgang Enard
Apr 12, 2017·Journal of Neurochemistry·Thomas ArendtUwe Ueberham
Aug 17, 2018·Scientific Reports·Risako NakaiMasanori Imamura
Feb 12, 2021·Scientific Reports·Johanna GeuderWolfgang Enard
Jun 11, 2021·Journal of Medical Primatology·Christina Cloutier BarbourElizabeth Hammond
Jun 10, 2014·Journal of Proteome Research·Cecilia LindskogFredrik Pontén

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