Functional profile of CD4+ and CD8+ T cells in latently infected individuals and patients with active TB

Tuberculosis
Nancy D MarinLuis F García

Abstract

Tuberculosis (TB) is one of the most important infectious diseases around the world. Several studies have focused on the identification of correlates of protection against TB. Most of them have concentrated on the study of IFN-γ due to its robust association with protection against TB. However, given the complexity of the immune response elicited after Mtb infection, other cytokines should also be considered. In the present study, we evaluated Th1 and Th17 responses and their association with the protection or development of active disease. Therefore, non infected individuals (nonTBi), latently infected individuals (LTBi) and patients with active TB (ATB) were studied. The evaluation of the number of cytokine producing cells by ELISPOT showed a higher number of IFN-γ-producing cells in ATB patients, but no differences were found regarding the number of IL-17 producing cells among studied groups. The evaluation of IFN-γ, IL-2, TNF-α and IL-17 producing CD4+ and CD8+ T cells at 1 day and 6 days of stimulation with mycobacterial antigens suggests the presence of functional signatures associated with latency or active TB. The results presented herein suggest the possible use of the evaluation of Th1-type cytokines, such as IFN-γ an...Continue Reading

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Citations

Feb 24, 2015·Immunological Reviews·Luke D JasenoskyAnne E Goldfeld
Sep 13, 2013·Tuberculosis·Harapan HarapanDaniela M Cirillo
Aug 5, 2014·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Guo-Qiang WangJu-Xia Niu
Aug 1, 2015·Ocular Immunology and Inflammation·Soumyava BasuNarsing A Rao
Nov 10, 2018·BMC Immunology·Karima SahmoudiFouad Seghrouchni
Mar 23, 2021·Immunological Reviews·Jeffrey MorganCecilia S Lindestam Arlehamn
May 1, 2021·Pathogens·Magdalena DruszczynskaWieslawa Rudnicka
Aug 2, 2021·International Immunopharmacology·Shuang QinXiangyang Lin

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