Functional properties of human muscle spindles

Journal of Neurophysiology
Vaughan G Macefield, Thomas P Knellwolf

Abstract

Muscle spindles are ubiquitous encapsulated mechanoreceptors found in most mammalian muscles. There are two types of endings, primary and secondary, and both are sensitive to changes in muscle length and velocity, with the primary endings having a greater dynamic sensitivity. Unlike other mechanoreceptors in the somatosensory system, muscle spindles are unique in possessing motor innervation, via γ-motoneurons (fusimotor neurons), that control their sensitivity to stretch. Much of what we know about human muscles spindles comes from studying the behavior of their afferents via intraneural microelectrodes (microneurography) inserted into accessible peripheral nerves. We review the functional properties of human muscle spindles, comparing and contrasting with what we know about the functions of muscle spindles studied in experimental animals. As in the cat, many human muscle spindles possess a background discharge that is related to the degree of muscle stretch, but mean firing rates are much lower (~10 Hz). They can faithfully encode changes in muscle fascicle length in passive conditions, but higher level extraction of information is required by the central nervous system to measure changes in muscle length during muscle contra...Continue Reading

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Citations

Jul 29, 2018·The Journal of Physiology·Stephen A KlassenJ Kevin Shoemaker
Aug 11, 2018·Current Opinion in Neurology·Stephan Kröger
Jan 31, 2019·Journal of Neurophysiology·Lyndon J SmithAlexander R Burton
Apr 3, 2020·Journal of Applied Physiology·Zoë J DjajadikartaJanet L Taylor
May 27, 2020·The Journal of Physiology·Lyndon SmithVaughan G Macefield
Sep 20, 2018·Journal of Neurophysiology·Lyndon J SmithVaughan G Macefield
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Nov 30, 2020·Journal of Manipulative and Physiological Therapeutics·Jennifer F MullinsArthur J Nitz
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Jan 8, 2021·Skeletal Muscle·Stephan Kröger, Bridgette Watkins
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Apr 14, 2021·Musculoskeletal Science & Practice·Michel W CoppietersPaul W Hodges
May 27, 2021·Journal of Neural Engineering·Jakob Dideriksen, Francesco Negro
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Jun 10, 2021·Journal of Manipulative and Physiological Therapeutics·Carla R LimaWilliam R Reed
Jul 21, 2021·International Journal of Sports Medicine·Georgios TrypidakisFrancesco Negro

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