Functional properties of the human ventral mesencephalic neural stem cell line hVM1

Experimental Neurology
Jan TønnesenMerab Kokaia

Abstract

The human fetal ventral mesencephalon-derived stem cell line, hVM1, yields high number of tyrosine hydroxylase-expressing presumed dopaminergic neurons upon in vitro differentiation. Here we report that cells generated from this line differentiate into a neuronal phenotype, express electrophysiological properties of functional neurons and respond to neurotransmitters in vitro. However, the electrophysiological properties are immature and the cells require longer maturation time than possible under in vitro conditions.

References

Jul 30, 2002·The Journal of Biological Chemistry·Julie LothariusPatrik Brundin
Dec 10, 2003·Oncogene·Jonas A Nilsson, John L Cleveland
Mar 17, 2004·Experimental Cell Research·Ana VillaAlberto Martinez-Serrano
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Olle Lindvall, Anders Björklund
Dec 7, 2007·The Journal of Clinical Investigation·Clare L ParishErnest Arenas
Apr 9, 2008·Stem Cells and Development·Ugur SalliKent E Vrana
Mar 31, 2009·Experimental Cell Research·Ana VillaAlberto Martínez-Serrano

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Citations

Aug 7, 2012·Journal of Cellular and Molecular Medicine·A Alwin Prem AnandV Kokila Vani
Dec 24, 2010·Cell Transplantation·Jana Mejía-ToiberMagda Giordano

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