Functional protein C levels during the early phase of clinical acute pancreatitis

Pancreas
Benoy Idicula Babu, Ajith K Siriwardena

Abstract

Protein C modulates microvascular thrombosis in sepsis, with levels being depleted in severe cases. Similar changes occur in necrotizing acute pancreatitis (AP). However, little is known of the pathophysiological characteristics of endogenous protein C early in the disease course of AP. This study undertakes an evaluation of protein C levels in AP. In a consecutive series of 57 patients with AP, the chromogenic substrate method was used to determine functional protein C levels in plasma. Protein C activity and variables required for the calculation of Acute Physiology and Chronic Health Evaluation II (APACHE II) scores were assessed at admission and 24 and 48 hours after admission. The median functional protein C level was 97 U/dL (range, 41-178 U/dL) on admission and 96 U/dL (range, 46-170 U/dL) 24 hours after admission. There was no significant difference in the functional protein C levels between the patients with an admission APACHE score of 8 or higher and those with lower APACHE II scores. Linear regression plots showed a nonsignificant trend to the lower levels of functional protein C activity in those patients with higher APACHE II scores. In human AP, functional protein C levels are conserved in mild disease. However, ...Continue Reading

References

Mar 1, 1987·The Journal of Clinical Investigation·F B TaylorK E Blick
Jan 1, 1993·Annales de chirurgie·E L Bradley
Mar 10, 2001·The New England Journal of Medicine·G R BernardUNKNOWN Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
Nov 8, 2002·Archives of Pathology & Laboratory Medicine·Kandice Kottke-Marchant, Philip Comp
Sep 13, 2003·Chest·Charles T Esmon
Jul 1, 2005·Critical Care : the Official Journal of the Critical Care Forum·Levent YamanelTahir Unal
Jan 20, 2006·Critical Care : the Official Journal of the Critical Care Forum·Outi LindstromJari Petaja
Mar 18, 2006·Critical Care : the Official Journal of the Critical Care Forum·Jan A Hazelzet
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Lisa J ToltlPatricia C Y Liaw

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