PMID: 3762232Sep 1, 1986Paper

Functional rearrangement of lymphohemopoietic system in heterochronically parabiosed mice

Mechanisms of Ageing and Development
A V SidorenkoG M Butenko

Abstract

This study examines some characteristics of the lymphohaemopoietic system of heterochronically parabiosed CBA mice. It was found that a decline of the primary immune response in a young mouse sutured with an old one is accompanied with the diminution of: bone marrow and thymus cellularity; thymus weight; haemopoietic stem cells (CFC-S) and granulocyte-macrophage precursor cells (CFC-C) contents in the femur, and stromal precursor cell (CFC-F) contents both in the femur and thymus. All the indices tested, including the immune response level, in old parabionts vs. old single mice remained unchanged. In the spleen, the considerable variations of splenic weights in the mice of different control and experimental groups have been found. At the same time, no significant changes in the cellularity and CFC-F number in the spleen of all examined groups of animals have been observed. The findings strongly indicate the considerable rearrangement of lymphohaemopoietic and stromal tissues in the central organs of the immune system, namely, bone marrow and thymus of young mice due to the parabiosis with old ones.

References

Jan 1, 1979·Mechanisms of Ageing and Development·M M Kay
Sep 1, 1977·Mechanisms of Ageing and Development·H Tauchi, K Hasegawa
Jun 1, 1966·The Australian Journal of Experimental Biology and Medical Science·T R Bradley, D Metcalf
Apr 1, 1972·Journal of Gerontology·V H Jolma, Z Hruza
Jul 1, 1982·Mechanisms of Ageing and Development·M L Tyan
Jun 1, 1983·British Journal of Haematology·A H PiersmaK G Brockbank
Mar 1, 1982·Mechanisms of Ageing and Development·Y GozesN Trainin
Nov 1, 1984·Journal of the American Academy of Dermatology·B A Gilchrest
Dec 1, 1984·Mechanisms of Ageing and Development·M M Kay
May 1, 1983·Mechanisms of Ageing and Development·K G BrockbankC M van Peer
Sep 1, 1983·American Journal of Hematology·M Tavassoli, A Friedenstein
Mar 1, 1983·Biulleten' eksperimental'noĭ biologii i meditsiny·A V Sidorenko
Jan 1, 1982·Journal of Cellular Physiology. Supplement·T M Dexter
Jan 1, 1982·Experimental Gerontology·M M Ghoneum, N Egami
Nov 1, 1981·Mechanisms of Ageing and Development·K I Matthews, D A Crouse
Jan 1, 1980·Mechanisms of Ageing and Development·H Tauchi, T Sato
Apr 26, 1963·Science·N K Jerne, A A Nordin

❮ Previous
Next ❯

Citations

Oct 6, 2007·Stem Cell Reviews·Andrew S Brack, Thomas A Rando
May 30, 1990·Mechanisms of Ageing and Development·A V SidorenkoG M Butenko
Apr 27, 2012·Rejuvenation Research·Iryna PishelGennadij Butenko
Jan 3, 2019·The Journal of Clinical Investigation·Ashley LauStefan G Tullius
Nov 11, 1991·Journal of Virology·K M CarboneG B Vogelsang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.