Functional recovery after human heart transplantation is related to the metabolic condition of the hypothermic donor heart

Circulation
J O van DobbenburghC J Van Echteld

Abstract

Although strict selection criteria are being used for the acceptance of human donor hearts for transplantation, problems with respect to functional recovery on reperfusion sometimes still occur. Therefore, evaluation of the viability of a human donor heart before implantation during heart transplantation may be of great value. In the present study, the energy metabolism of 25 excised human donor hearts arrested with St Thomas' Hospital No. 2 cardioplegic solution was evaluated noninvasively by use of 31P magnetic resonance spectroscopy (MRS) before implantation and was correlated with myocardial function measured with thermodilution in heart transplant patients. No significant correlation was observed between the cardiac index of heart transplant patients during the first hours after transplantation and the phosphocreatine/ATP (r = .13, P = .54), inorganic phosphate/ATP (r = .26, P = .21), phosphomonoesters/ATP (r = .02, P = .92), or phosphocreatine/inorganic phosphate (r = .16, P = .44) ratio or the intracellular pH (r = .06, P = .78) at the time of reperfusion. However, 1 week after transplantation, a significant correlation was observed between the cardiac index and the phosphocreatine/ATP (r = .49, P = .01), phosphomonoeste...Continue Reading

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Citations

Jun 24, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·B BiagioliF Carlucci
Apr 16, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Serban C StoicaStephen R Large
Sep 15, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·G J BruinsmaC J Van Echteld
Oct 22, 2011·Progress in Cardiovascular Diseases·Cameron J HollowayStefan Neubauer
Sep 24, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Serban C Stoica
Feb 2, 2021·Journal of the American Heart Association·Martina BonaSarah L Longnus

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