Functional recovery and facial motoneuron survival are influenced by immunodeficiency in crush-axotomized mice.

Experimental Neurology
Taylor BeahrsKathryn J Jones

Abstract

Facial nerve axotomy is a well-described injury paradigm for peripheral nerve regeneration and facial motoneuron (FMN) survival. We have previously shown that CD4(+) T helper (Th) 1 and 2 effector subsets develop in the draining cervical lymph node, and that the IL-4/STAT-6 pathway of Th2 development is critical for FMN survival after transection axotomy. In addition, delayed behavioral recovery time in immunodeficient mice may be due to the absence of T and B cells. This study utilized a crush axotomy paradigm to evaluate FMN survival and functional recovery in WT, STAT-6 KO (impaired Th2 response), T-Bet KO (impaired Th1 response), and RAG-2 KO (lacking mature T and B cells) mice to elucidate the contributions of specific CD4(+) T cell subsets in motoneuron survival and recovery mechanisms. STAT-6 KO and RAG-2 KO mice exhibited decreased FMN survival after crush axotomy compared to WT, supporting a critical role for the Th2 effector cell in motoneuron survival before target reconnection. Long term FMN survival was sustained through 10 wpo after crush axotomy in both WT and RAG-2 KO mice, indicating that target derived neurotrophic support maintains FMN survival after target reconnection. In addition, RAG-2 KO mice exhibited d...Continue Reading

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Citations

Sep 1, 2011·Journal of Neuroinflammation·Andrew D GaudetMatt S Ramer
Jun 27, 2014·Experimental Neurology·Ali MehannaIgor Jakovcevski
Jul 5, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Julia K Terzis, Katerina Anesti
Jul 8, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kathryn J JonesVirginia M Sanders
Aug 21, 2015·Journal of Neural Transmission·Chi Wang IpJens Volkmann
Jun 11, 2016·Journal of Neuroinflammation·Fabian SzepanowskiBernd C Kieseier
Mar 16, 2017·Plastic and Reconstructive Surgery. Global Open·Seden AkdagliSam P Most
May 6, 2017·PloS One·Christopher R Cashman, Ahmet Hoke
Oct 17, 2017·Brain, Behavior, and Immunity·D O SetterK J Jones
Mar 24, 2021·Neurorehabilitation and Neural Repair·John M DainesMatthew D Wood
Jan 13, 2022·Neural Regeneration Research·Igor JakovcevskiMelitta Schachner

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