Abstract
Facial nerve axotomy is a well-described injury paradigm for peripheral nerve regeneration and facial motoneuron (FMN) survival. We have previously shown that CD4(+) T helper (Th) 1 and 2 effector subsets develop in the draining cervical lymph node, and that the IL-4/STAT-6 pathway of Th2 development is critical for FMN survival after transection axotomy. In addition, delayed behavioral recovery time in immunodeficient mice may be due to the absence of T and B cells. This study utilized a crush axotomy paradigm to evaluate FMN survival and functional recovery in WT, STAT-6 KO (impaired Th2 response), T-Bet KO (impaired Th1 response), and RAG-2 KO (lacking mature T and B cells) mice to elucidate the contributions of specific CD4(+) T cell subsets in motoneuron survival and recovery mechanisms. STAT-6 KO and RAG-2 KO mice exhibited decreased FMN survival after crush axotomy compared to WT, supporting a critical role for the Th2 effector cell in motoneuron survival before target reconnection. Long term FMN survival was sustained through 10 wpo after crush axotomy in both WT and RAG-2 KO mice, indicating that target derived neurotrophic support maintains FMN survival after target reconnection. In addition, RAG-2 KO mice exhibited d...Continue Reading
References
Jul 1, 1989·Experimental Neurology·K A KujawaK J Jones
Apr 18, 1996·Nature·K ShimodaJ N Ihle
Feb 1, 1997·Molecular Neurobiology·S Y Fu, T Gordon
May 1, 1999·Experimental Neurology·K KuzisF P Eckenstein
May 19, 2000·Cytokine & Growth Factor Reviews·K Takeda, S Akira
Jun 13, 2000·Oncogene·A L WursterM J Grusby
Oct 6, 2000·Journal of Neuroscience Research·C J SerpeK J Jones
Jan 12, 2002·Science·Susanne J SzaboLaurie H Glimcher
Dec 14, 2002·Brain, Behavior, and Immunity·Craig J SerpeKathryn J Jones
May 30, 2003·Pharmacological Reviews·K AsadullahH D Volk
Aug 30, 2003·Immunologic Research·Meixia Zhou, Wenjun Ouyang
Mar 9, 2004·Brain Research. Brain Research Reviews·Linda B Moran, Manuel B Graeber
May 7, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Susanna C ByramKathryn J Jones
Dec 8, 2004·Brain, Behavior, and Immunity·Kathryn J JonesVirginia M Sanders
Jan 25, 2005·Brain, Behavior, and Immunity·Craig J SerpeKathryn J Jones
Jun 30, 2006·Experimental Neurology·Cynthia A DeboyKathryn J Jones
Nov 21, 2007·Brain, Behavior, and Immunity·Junping XinKathryn J Jones
Jun 10, 2008·Journal of Neuroimmunology·Grace K HaJohn M Petitto
Jul 1, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Laura E T HetzlerEileen M Foecking
Aug 9, 2008·Neuroscience Letters·Grace K HaJohn M Petitto
Feb 1, 1946·The Anatomical Record·M ABERCROMBIE
Citations
Sep 1, 2011·Journal of Neuroinflammation·Andrew D GaudetMatt S Ramer
Jun 27, 2014·Experimental Neurology·Ali MehannaIgor Jakovcevski
Jul 5, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Julia K Terzis, Katerina Anesti
Jul 8, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kathryn J JonesVirginia M Sanders
Jan 16, 2014·The Journal of Comparative Neurology·Melissa M HaulcombKathryn J Jones
Aug 21, 2015·Journal of Neural Transmission·Chi Wang IpJens Volkmann
Jun 11, 2016·Journal of Neuroinflammation·Fabian SzepanowskiBernd C Kieseier
Mar 16, 2017·Plastic and Reconstructive Surgery. Global Open·Seden AkdagliSam P Most
Aug 10, 2019·Muscle & Nerve·Brett DavisJay Agarwal
May 4, 2018·Neural Regeneration Research·Tohru TateshitaAkiyoshi Kajikawa
May 6, 2017·PloS One·Christopher R Cashman, Ahmet Hoke
Mar 29, 2020·The Laryngoscope·S Ahmed AliMichael J Brenner
Oct 17, 2017·Brain, Behavior, and Immunity·D O SetterK J Jones
Mar 24, 2021·Neurorehabilitation and Neural Repair·John M DainesMatthew D Wood
Jan 13, 2022·Neural Regeneration Research·Igor JakovcevskiMelitta Schachner