PMID: 11921049Mar 29, 2002Paper

Functional recovery and neuroanatomical plasticity following middle cerebral artery occlusion and IN-1 antibody treatment in the adult rat

Annals of Neurology
Catherine M PapadopoulosGwendolyn L Kartje

Abstract

Stroke is a prevalent and devastating disorder, and no treatment is currently available to restore lost neuronal function after stroke occurs. One unique therapy that may improve functional recovery after stroke is blockade of the neurite inhibitory protein Nogo-A with the monoclonal antibody IN-1, through enhancement of neuroanatomical plasticity from uninjured areas of the central nervous system. In the present study, we combined IN-1 treatment with an ischemic lesion (permanent middle cerebral artery occlusion) to determine the effect of Nogo-A neutralization on cortical plasticity and functional recovery. We report here that, following ischemic stroke and treatment with IN-1, adult rats demonstrated functional recovery on a forelimb-reaching task and new cortico-efferent projections from the opposite, unlesioned hemisphere. These results support the efficacy of Nogo-A blockade as a treatment for ischemic stroke and implicate plasticity from the unlesioned hemisphere as a mechanism for recovery.

References

Aug 15, 1992·The Journal of Comparative Neurology·B KolbD van der Kooy
Jan 1, 1989·Progress in Neurobiology·B Kolb, I Q Whishaw
Jul 1, 1986·Stroke; a Journal of Cerebral Circulation·S T ChenJ D Balentine
Mar 1, 1986·Brain Research·E J NeafseyR R Terreberry
Aug 8, 1986·The Journal of Comparative Neurology·G Kartje-TillotsonA J Castro
Sep 22, 1985·The Journal of Comparative Neurology·C G NausA W Hrycyshyn
Sep 1, 1983·The Journal of Comparative Neurology·A J Castro, G A Mihailoff
Feb 1, 1980·Physiology & Behavior·G Kartje-Tillotson, A J Castro
Nov 1, 1995·Stroke; a Journal of Cerebral Circulation·R P StroemerC E Hulsebosch
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y CaoD N Levin
Oct 1, 1993·Brain : a Journal of Neurology·L J CarrJ A Stephens
Jan 1, 1997·Brain Research Bulletin·A Guillamón, S Segovia
Dec 5, 1997·Brain Research. Molecular Brain Research·T N LinC Y Hsu
Feb 17, 1998·The European Journal of Neuroscience·S Rowntree, B Kolb
May 30, 1998·Journal of Neuroscience Methods·T SaitoT Nemoto
Jun 17, 1998·Stroke; a Journal of Cerebral Circulation·M Kelly-HayesC A Trombly
Dec 23, 1999·Current Opinion in Neurobiology·R J Nudo
Jun 6, 2000·Trends in Neurosciences·S C Cramer, M Chopp
Jul 25, 2000·Trends in Neurosciences·A N Iwaniuk, I Q Whishaw

❮ Previous
Next ❯

Citations

Aug 25, 2007·Experimental Brain Research·Shih-Yen TsaiGwendolyn L Kartje
Jan 1, 2014·Journal of Neural Transmission·Dirk M HermannAurel Popa-Wagner
Oct 8, 2013·Translational Stroke Research·Chye Yun YuPing Liao
Sep 3, 2003·Biochemical and Biophysical Research Communications·Changman ZhouJohn H Zhang
Mar 17, 2004·Current Opinion in Neurobiology·Martin E Schwab
May 5, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·John H ZhangAustin Colohan
Apr 12, 2003·Trends in Neurosciences·Aaron W McGee, Stephen M Strittmatter
Dec 11, 2003·Molecular and Cellular Neurosciences·Przemyslaw S SapiehaAdriana Di Polo
Dec 12, 2003·Nature Reviews. Drug Discovery·Daniel H S LeeDinah W Y Sah
Sep 4, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hsu-Ko Kuo, Lewis A Lipsitz
Aug 23, 2007·ILAR Journal·Jeffrey A KleimDeAnna L Adkins
Aug 31, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Irin C Maier, Martin E Schwab
Aug 31, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Betty P LiuStephen M Strittmatter
May 17, 2006·Clinical and Experimental Pharmacology & Physiology·Beng Ti AngZhi Cheng Xiao
Mar 11, 2003·Annual Review of Neuroscience·Samuel David, Steve Lacroix
Feb 23, 2008·Cerebrovascular Diseases·Matthias EndresUlrich Dirnagl
Mar 1, 2008·Stroke; a Journal of Cerebral Circulation·S Thomas Carmichael
May 10, 2008·Stroke; a Journal of Cerebral Circulation·Joseph L CheatwoodGwendolyn L Kartje
Nov 29, 2008·Stroke; a Journal of Cerebral Circulation·Catherine M PapadopoulosWilliam A Wolf
Nov 23, 2010·Stroke; a Journal of Cerebral Circulation·Shih-Yen TsaiGwendolyn L Kartje
Jan 8, 2008·Genome Biology·Yvonne S Yang, Stephen M Strittmatter
Jun 26, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laila ZaiLarry I Benowitz
Nov 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William B J Cafferty, Stephen M Strittmatter
Apr 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laila ZaiLarry I Benowitz
Oct 25, 2008·Regenerative Medicine·Noreen M GervasiJames W Fawcett
Jan 14, 2005·The Keio Journal of Medicine·Barbro B Johansson
Dec 21, 2013·Brain : a Journal of Neurology·Nicolas T LindauMartin E Schwab
May 8, 2013·Therapeutic Delivery·Marcus W BrazierSteven J Collins
Apr 19, 2007·Neurological Research·Yu TakedaHidenori Kobayashi
Jun 14, 2014·Neuroscience Letters·Nuttha KlincumhomMongkol Techakumphu
Feb 1, 2013·Stroke Research and Treatment·Jerzy Krupinski, Mark Slevin
Apr 23, 2004·Expert Opinion on Therapeutic Targets·Kevin Pong
Oct 16, 2002·The Journal of Cell Biology·Caroline PotMartin E Schwab
Feb 13, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jessica Livingston-ThomasDale Corbett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Andrew B SeymourGwendolyn L Kartje
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jung-Kil LeeStephen M Strittmatter
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Christoph WiessnerMartin E Schwab
© 2022 Meta ULC. All rights reserved