Functional recovery of completely denervated muscle: implications for innervation of tissue-engineered muscle.

Tissue Engineering. Part a
Sung-Bum KangJames J Yoo

Abstract

Tissue-engineered muscle has been proposed as a solution to repair volumetric muscle defects and to restore muscle function. To achieve functional recovery, engineered muscle tissue requires integration of the host nerve. In this study, we investigated whether denervated muscle, which is analogous to tissue-engineered muscle tissue, can be reinnervated and can recover muscle function using an in vivo model of denervation followed by neurotization. The outcomes of this investigation may provide insights on the ability of tissue-engineered muscle to integrate with the host nerve and acquire normal muscle function. Eighty Lewis rats were classified into three groups: a normal control group (n=16); a denervated group in which sciatic innervations to the gastrocnemius muscle were disrupted (n=32); and a transplantation group in which the denervated gastrocnemius was repaired with a common peroneal nerve graft into the muscle (n=32). Neurofunctional behavior, including extensor postural thrust (EPT), withdrawal reflex latency (WRL), and compound muscle action potential (CMAP), as well as histological evaluations using alpha-bungarotoxin and anti-NF-200 were performed at 2, 4, 8, and 12 weeks (n=8) after surgery. We found that EPT was...Continue Reading

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Citations

Dec 21, 2012·Tissue Engineering. Part B, Reviews·Matthew B Fisher, Robert L Mauck
Jul 4, 2015·International Journal of Molecular Sciences·Andrea PorzionatoRaffaele De Caro
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Feb 13, 2013·Journal of Tissue Engineering and Regenerative Medicine·Sung-Bum KangJames J Yoo
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Feb 14, 2021·Npj Regenerative Medicine·Suradip DasD Kacy Cullen
Sep 3, 2021·Neural Regeneration Research·Paolo RaffaAnna Urciuolo

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Methods Mentioned

BETA
force measurement

Software Mentioned

SPSS

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