Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells

Circulation
Woei-Cherng ShyuHung Li

Abstract

Stroke is a leading cause of death and disability worldwide; however, no effective treatment currently exists. Rats receiving subcutaneous granulocyte colony-stimulating factor (G-CSF) showed less cerebral infarction, as evaluated by MRI, and improved motor performance after right middle cerebral artery ligation than vehicle-treated control rats. Subcutaneous administration of G-CSF enhanced the availability of circulating hematopoietic stem cells to the brain and their capacity for neurogenesis and angiogenesis in rats with cerebral ischemia. G-CSF induced increases in bone marrow cell mobilization and targeting to the brain, reducing the volume of cerebral infarction and improving neural plasticity and vascularization.

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L GarofaloA C Cuello
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L R WilliamsF H Gage
May 15, 1999·Science·B E PetersenJ P Goff
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·D OrlicP Anversa
Jan 22, 2003·Journal of Immunological Methods·Margherita Mariani, Paola Panina-Bordignon
Feb 5, 2003·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Xiaoguang ChenMichael Chopp

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Citations

Nov 14, 2007·Journal of Applied Genetics·Mariusz Z RatajczakMagdalena Kucia
Jul 24, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Li-Kai TsaiHung Li
Sep 17, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Shao-Chih ChiuDemeral David Liu
Jan 15, 2009·Acta Neuropathologica·Heike Beck, Karl H Plate
Mar 14, 2009·Acta Neuropathologica·Yi Ping LiuRaghu Vemuganti
Oct 15, 2010·Journal of Neural Transmission·Yu Luo
Mar 27, 2007·Journal of Assisted Reproduction and Genetics·Nicolas H ZechSonja Koestenbauer
Dec 29, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yan HongQin Li
Jul 3, 2007·Current Treatment Options in Cardiovascular Medicine·Juan F ArenillasAntoni Dávalos
May 24, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Preeti Sahota, Sean I Savitz
Jun 1, 2005·Brain Research·Cesar V BorlonganDavid C Hess
Jan 19, 2011·Nature Reviews. Neurology·Michael A Dimyan, Leonardo G Cohen
May 23, 2007·The Journal of Experimental Medicine·Kuen-Jer TsaiChe-Kun James Shen
Nov 13, 2010·Age and Ageing·Soma BanerjeeJeremy Chataway
Feb 7, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jeffrey J Ross, Catherine M Verfaillie
Jul 12, 2005·The Journal of Clinical Investigation·Armin SchneiderWolf-Rüdiger Schäbitz
Jul 4, 2008·The Journal of Clinical Investigation·Woei-Cherng ShyuHung Li
Oct 20, 2006·BMC Biology·Armin SchneiderWolf-Rüdiger Schäbitz
Feb 10, 2010·Experimental & Translational Stroke Medicine·Jens MinnerupWolf-Rüdiger Schäbitz
Apr 15, 2010·Experimental & Translational Stroke Medicine·Rainer KollmarStefan Schwab
Mar 7, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Woei-Cherng ShyuHung Li
Oct 4, 2008·The Tohoku Journal of Experimental Medicine·Xifa LanChaodong Zhang
Oct 24, 2012·Vascular Health and Risk Management·Soma BanerjeeJeremy Chataway
Mar 18, 2008·Neurosurgical Focus·Raphael GuzmanGary K Steinberg
May 19, 2012·Regenerative Medicine·John W ThwaitesNagy Habib

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