PMID: 11899190Mar 20, 2002Paper

Functional recovery of the native heart after cardiomyoplasty in sheep with heart failure: passive and dynamic effects of volume loading

The Annals of Thoracic Surgery
Kazuaki ShirotaS N Hunyor

Abstract

Dynamic cardiomyoplasty (d-CMP) encourages reverse remodeling and improved contractility and stroke work (SW) efficiency of the failing native heart. This contrasts with passive cardiomyoplasty (p-CMP), which provides "passive girdling." To further evaluate pump recovery we assessed native left ventricular performance (without assist) 6 months after dynamic and passive CMP in sheep with heart failure with acute volume loading. Heart failure (left ventricular ejection fraction 26%+/-8%) induced by coronary microembolization was followed by CMP in 11 sheep. After 8 weeks of muscle "training," paced cardiac assist was undertaken in the d-CMP group (n = 6). Five sheep with heart failure served as controls. Six months later the pressure-volume relationship was derived before and after volume loading by colloid solution. Latissimus dorsi muscle pacing was previously ceased in the d-CMP group. Volume loading increased left ventricular end-diastolic volume and pressure in all groups. After volume loading in d-CMP, the SW and pressure-volume area were increased, and SW efficiency remained unchanged. In p-CMP neither variable changed, whereas in control heart failure SW efficiency decreased due to a rise in pressure-volume area with stab...Continue Reading

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Jan 13, 2001·The Annals of Thoracic Surgery·K ShirotaS N Hunyor

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Citations

May 9, 2003·The Annals of Thoracic Surgery·Juan C ChachquesAlain F Carpentier
Jan 13, 2005·Artificial Organs·Sonna M PatelDon B Olsen
Apr 8, 2010·The Journal of Surgical Research·Jan D SchmittoFrederick Y Chen
Sep 1, 2004·The Annals of Thoracic Surgery·Alexander LembckeWolfgang F Konertz
Jan 1, 2010·Expert Opinion on Drug Discovery·Hirofumi RokutanJochen Springer
Nov 25, 2004·The International Journal of Artificial Organs·P FeindtE Gams

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