Functional regulation of PI3K-associated signaling in the accumbens by binge alcohol drinking in male but not female mice

Neuropharmacology
Debra K CozzoliDeborah A Finn

Abstract

It is well established that binge alcohol consumption produces alterations in Group 1 metabotropic glutamate receptors (mGlus) and related signaling cascades in the nucleus accumbens (NAC) of adult male mice, but female and adolescent mice have not been examined. Thus, the first set of studies determined whether repeated binge alcohol consumption produced similar alterations in protein and mRNA levels of Group 1 mGlu-associated signaling molecules in the NAC of male and female adult and adolescent mice. The adult (9 weeks) and adolescent (4 weeks) C57BL/6J mice were exposed to 7 binge alcohol sessions every 3rd day while controls drank water. Repeated binge alcohol consumption produced sexually divergent changes in protein levels and mRNA expression for Group 1 mGlus and downstream signaling molecules in the NAC, but there was no effect of age. Binge alcohol intake decreased mGlu5 levels in females, whereas it decreased indices of phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), 4E-binding protein 1, and p70 ribosomal protein S6 kinase in males. Expression of genes encoding mGlu1, mGlu5, the NR2A subunit of the NMDA receptor, and Homer2 were all decreased by binge alcohol consumption in males, while femal...Continue Reading

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Citations

May 8, 2016·Alcoholism, Clinical and Experimental Research·Marina GuizzettiFarida Sohrabji
Sep 17, 2020·International Journal of Molecular Sciences·Daniel R LathenAdrian Rothenfluh
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Sep 9, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chenyuan QinWei Yang

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