Functional relations of cerebellar modules of the cat.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Kris M HornAlan R Gibson

Abstract

The cerebellum consists of parasagittal zones that define fundamental modules of neural processing. Each zone receives input from a distinct subdivision of the inferior olive (IO)-activity in one olivary subdivision will affect activity in one cerebellar module. To define functions of the cerebellar modules, we inactivated specific olivary subdivisions in six male cats with a glutamate receptor blocker. Olivary inactivation eliminates Purkinje cell complex spikes, which results in a high rate of Purkinje cell simple spike discharge. The increased simple spike discharge inhibits output from connected regions of the cerebellar nuclei. After inactivation, behavior was evaluated during a reach-to-grasp task and during locomotion. Inactivation of each subdivision produced unique behavioral deficits. Performance of the reach-to-grasp task was affected by inactivation of the rostral dorsal accessory olive (rDAO) and the rostral medial accessory olive (rMAO) and, possibly, the principal olive. rDAO inactivation produced paw drag during locomotion and a deficit in grasping the handle during the reach-to-grasp task. rMAO inactivation caused the cats to reach under the handle and produced severe limb drag during locomotion. Inactivation o...Continue Reading

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Citations

Sep 15, 2010·The Cerebellum·Nadia L Cerminara, Richard Apps
Aug 7, 2012·The Cerebellum·Stacey L Reeber, Kevin J O'Donovan
Apr 9, 2013·The Cerebellum·Vincenzo PerciavalleRaudel Sánchez-Campusano
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Neal H Barmack, Vadim Yakhnitsa
Sep 9, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Justin A BarnesTimothy J Ebner
Oct 3, 2012·The Journal of Physiology·K M HornA R Gibson
Jul 10, 2013·The Journal of Physiology·Paul DeanHenrik Jörntell
Jan 18, 2012·The Journal of Physiology·Jens C ReklingHenrik Jahnsen
Oct 13, 2010·Brain Research Reviews·Enrico MugnainiMarco Martina
Jan 8, 2015·Frontiers in Systems Neuroscience·Jan Voogd
Jan 5, 2011·PloS One·Satoru Onodera, T Philip Hicks
Apr 5, 2017·Nature Communications·Joshua J White, Roy V Sillitoe
Oct 23, 2019·Frontiers in Cellular Neuroscience·Jason S Gill, Roy V Sillitoe
Nov 11, 2019·Disease Models & Mechanisms·Trace L StayRoy V Sillitoe
Oct 27, 2018·Frontiers in Neural Circuits·Lauren N MiterkoRoy V Sillitoe
Oct 15, 2021·Scientific Reports·Tetsuro FunatoDai Yanagihara

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