Functional relevance of miRNAs in premature ageing

Mechanisms of Ageing and Development
Xurde M CaraviaCarlos López-Otín

Abstract

Ageing is a complex biological process characterized by the progressive loss of biological fitness due to the accumulation of macromolecular and cellular damage that affects most living organisms. Moreover, ageing is an important risk factor for many pathologies, including cardiovascular diseases, neurological disorders, and cancer. However, the ageing rate can be modulated by genetic, nutritional, and pharmacological factors, highlighting the concept of "ageing plasticity". Progeroid syndromes are a group of rare genetic diseases that resemble many characteristics of physiological ageing. Accordingly, studies on these diseases have been very useful for gaining mechanistic insights in ageing biology. In recent years, a great effort has been made in ageing research and several works have confirmed that geromiRs, the growing subgroup of miRNAs implicated in ageing, are able to modulate organismal lifespan. However, very little is still known about the impact of miRNA in premature ageing. In this review, we will address the functional relevance of this class of small non-coding RNAs in the regulation of the hallmarks of progeroid syndromes. In addition, we will discuss the potential strategies for managing progeria based on geromi...Continue Reading

References

Mar 26, 2010·Nature·Cynthia J Kenyon

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Citations

Oct 23, 2018·PLoS Biology·Xurde M CaraviaCarlos López-Otín
Jul 30, 2020·International Journal of Molecular Sciences·Marta GerasymchukIgor Kovalchuk
Aug 28, 2021·Biomedicines·Yousra HamdanGabriel Malka

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