Functional relevance of SATB1 in immune regulation and tumorigenesis

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Krishna P SunkaraMary Bebawy

Abstract

The Special AT-rich Sequence Binding Protein 1 (SATB1) is a chromatin organiser and transcription factor which regulates numerous cellular processes such as differentiation, proliferation and apoptosis through effects on gene expression. SATB1 undergoes various post-translational modifications, which determine its interaction with co-activators and co-repressors to induce regulation of gene transcription. SATB1 is an identified oncogene, its increased expression is associated with poor prognosis in many cancers. This paper provides a review on SATB1-mediated immune responses and on its target genes in the context of tumorigenesis and tumour progression. Specifically, we discuss the role of SATB1 in tumour immunity, Epithelial to Mesenchymal Transition (EMT), metastasis and multidrug resistance. Therapeutic targeting of aberrant SATB1 may be an important strategy in the treatment of cancer.

References

Sep 5, 2002·Nature Reviews. Cancer·Suzanne Cory, Jerry M Adams
Oct 11, 2002·Nature·Dag YasuiTerumi Kohwi-Shigematsu
Apr 15, 2003·Nature Genetics·Shutao CaiTerumi Kohwi-Shigematsu
Aug 14, 2003·Human Molecular Genetics·David R FitzPatrickDavid T Bonthron
Dec 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eiichi SatoKunle Odunsi
Feb 10, 2006·Cancer Immunology, Immunotherapy : CII·Helena HarlinThomas F Gajewski
Sep 19, 2007·Cancer Research·Marilena V IorioCarlo M Croce
Mar 14, 2008·Nature·Hye-Jung HanTerumi Kohwi-Shigematsu
Oct 3, 2008·Cancer Research·Thales PapagiannakopoulosKenneth S Kosik
Nov 26, 2008·Nature Reviews. Cancer·Natalie Meyer, Linda Z Penn
Dec 24, 2008·Molecular and Cellular Biology·Prabhat Kumar PurbeySanjeev Galande
May 15, 2009·Nature Reviews. Cancer·Tarek Abbas, Anindya Dutta
Jun 3, 2009·The Journal of Clinical Investigation·Raghu Kalluri, Robert A Weinberg
Aug 1, 2009·Cancer Cell International·Neill PataniKefah Mokbel
Jul 3, 2010·Journal of the National Cancer Institute·Elizabeth IornsMarc Lippman
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sahar M A MahmoudAndrew R Green
May 21, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Christina I SelingerMaija R J Kohonen-Corish
Jul 20, 2011·Journal of Dermatological Science·Hongxiang ChenMasutaka Furue
Sep 21, 2011·The Journal of Cell Biology·Michael Y FessingVladimir A Botchkarev
May 16, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Wei TuDean Tian
Jun 5, 2012·The New England Journal of Medicine·Julie R BrahmerJon M Wigginton
Jun 12, 2012·Biochemical and Biophysical Research Communications·A M LenaE Candi
Jul 31, 2012·Journal of Translational Medicine·Sheng-Hua ChuPu-Cha Jiang
Oct 19, 2012·Molecular Medicine Reports·Sheng-Hua ChuPu-Cha Jiang
Nov 13, 2012·Cell Reports·Myrto DenaxaVassilis Pachnis
Jan 16, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Sheng-Hua ChuPu-Cha Jiang

❮ Previous
Next ❯

Citations

Dec 1, 2019·Drug Development Research·Mohammad AltamishGaurav Gupta
Nov 8, 2019·Journal of Cosmetic Dermatology·Yang-Chun XuPing Li
Dec 12, 2019·Drug Development Research·Zhaoji LuanLina Shi
Sep 15, 2020·Inflammation and Regeneration·Kaoru YamagataYoshiya Tanaka
May 28, 2019·Cancer Cell International·Xiaodan LuoLian Liu
Dec 29, 2020·Nucleus·Tomas Zelenka, Charalampos Spilianakis
Jul 16, 2019·Trends in Immunology·Paolo GiovanelliJuan R Cubillos-Ruiz
Oct 15, 2020·Personalized Medicine·Maria PapatsirouChristos K Kontos
Sep 30, 2021·Cellular and Molecular Life Sciences : CMLS·Samiksha KukalRitushree Kukreti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cancer Epigenetics Chromatin Complexes (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin complexes and their role in cancer epigenetics.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics and Chromatin (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin and its role in cancer epigenetics please follow this feed to learn more.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.