Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways.

The Journal of Biological Chemistry
Supurna GhoshM Sharon Stack

Abstract

Squamous cell carcinoma of the oral cavity is characterized by persistent, disorganized expression of integrin alpha3beta1 and enhanced production of urinary-type plasminogen activator (uPA) and its receptor (uPAR) relative to normal oral mucosa. Because multivalent aggregation of alpha3beta1 integrin up-regulates uPA and induces a dramatic co-clustering of uPAR, we explored the hypothesis that lateral ligation of alpha3beta1 integrin by uPAR contributes to uPA regulation in oral mucosal cells. To investigate mechanisms by which uPAR/alpha3beta1 binding enhances uPA expression, integrin-dependent signal activation was assessed. Both Src and ERK1/2 were phosphorylated in response to integrin aggregation, and blocking Src kinase activity completely abrogated ERK1/2 activation and uPA induction, whereas inhibition of epidermal growth factor receptor tyrosine kinase activity did not alter uPA expression. Proteinase up-regulation occurred at the transcriptional level and mutation of the AP1 (-1967) site in the uPA promoter blocked the uPAR/integrin-mediated transcriptional activation. Because uPAR is redistributed to clustered alpha3beta1 integrins, the requirement for uPAR/alpha3beta1 interaction in uPA regulation was assessed. Clu...Continue Reading

References

Nov 1, 1995·The Journal of Cell Biology·S MiyamotoK M Yamada
Jul 10, 1996·Experimental Cell Research·D OdaR Blanton
Sep 13, 1996·Science·Y WeiH A Chapman
Jul 3, 1997·International Journal of Cancer. Journal International Du Cancer·P A AndreasenM J Duffy
Aug 1, 1997·Head & Neck·W L HicksD P Shedd
Oct 10, 1998·International Journal of Cancer. Journal International Du Cancer·S M EllerbroekM S Stack
Aug 19, 2000·Cellular and Molecular Life Sciences : CMLS·P A AndreasenH H Petersen
Sep 9, 2000·Current Opinion in Cell Biology·L Ossowski, J A Aguirre-Ghiso
Oct 31, 2000·Microscopy Research and Technique·J C JonesL E Goldfinger
Sep 19, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K M HaasH Kosmehl
Jul 26, 2002·The Journal of Biological Chemistry·Hidayatullah G MunshiM Sharon Stack
Nov 14, 2002·Molecular Biology of the Cell·Cecile A W Geuijen, Arnoud Sonnenberg
Dec 4, 2002·Nature Reviews. Molecular Cell Biology·Francesco Blasi, Peter Carmeliet
Jul 17, 2003·International Journal of Cancer. Journal International Du Cancer·Masaki NagataRitsuo Takagi
Jul 23, 2003·Current Pharmaceutical Design·Matthias C KuglerHarold A Chapman
Oct 15, 2003·The Journal of Cell Biology·Feng ZhangHarold A Chapman
Mar 17, 2004·The Journal of Cell Biology·Hui WangRuth J Muschel
Oct 27, 2004·Experimental Cell Research·David Chodniewicz, Richard L Klemke
Nov 24, 2004·Cellular and Molecular Life Sciences : CMLS·H Myöhänen, A Vaheri
Feb 3, 2005·The Journal of Cell Biology·Ying WeiHarold A Chapman

❮ Previous
Next ❯

Citations

Mar 23, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Jiao YueJianfeng Chen
Dec 23, 2009·Nature Reviews. Molecular Cell Biology·Harvey W Smith, Chris J Marshall
Apr 27, 2011·The Journal of Biological Chemistry·Rebecca J BurkhalterM Sharon Stack
May 5, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sha ZhuMitchell A Olman
Apr 29, 2009·Blood·Young-Jun ParkEdward Abraham
Nov 12, 2009·Future Oncology·Ahmed H MekkawyMohammad H Pourgholami
Mar 29, 2014·Advances in Wound Care·Whitney M Longmate, C Michael Dipersio
Dec 17, 2015·Expert Opinion on Therapeutic Targets·Shih-Chi SuShun-Fa Yang
May 26, 2015·International Journal of Oncology·Marzena Wyganowska-Świątkowska, Jerzy Jankun
Dec 15, 2012·Thrombosis and Haemostasis·Nunzia MontuoriPia Ragno
Jun 6, 2015·Archives of Pathology & Laboratory Medicine·Lizandra JimenezJeffrey E Segall
Apr 4, 2014·The Journal of Investigative Dermatology·Dara S MissanC Michael DiPersio
Aug 16, 2011·Expert Opinion on Therapeutic Targets·Sita Subbaram, C Michael Dipersio
Oct 19, 2012·Cell Adhesion & Migration·Krishna Kumar Veeravalli, Jasti S Rao
Mar 9, 2007·Matrix Biology : Journal of the International Society for Matrix Biology·Roman M SalasznykPaula J McKeown-Longo
Jan 25, 2007·Blood·Sibylle von VietinghoffRalph Kettritz
Dec 5, 2018·Journal of Cellular and Molecular Medicine·Mari KawamuraShogo Takashiba
Jul 9, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chong LiZusen Fan
Sep 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew P Mazar
Jan 25, 2021·Drug Discovery Today·Cai YuanMingdong Huang
Dec 6, 2006·The Journal of Biological Chemistry·Ying WeiHarold A Chapman
Mar 21, 2008·European Journal of Cell Biology·Chris D Madsen, Nicolai Sidenius

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.