PMID: 7008802Jan 1, 1981Paper

Functional renal involvement in normotensive patients with progressive systemic sclerosis: impaired sodium excretion during isotonic saline infusion

Arthritis and Rheumatism
A D'AngeloS Todesco

Abstract

An intravenous infusion of 2,000 ml isotonic saline was performed in 8 normotensive, normoreninemic patients with progressive systemic sclerosis. None of them had clinical evidence of renal disease. Total and proximal fractional excretion of sodium was reduced when compared with that of 8 normal subjects. No correlation was found with para-aminohippurate (PAH) clearance values. Two years after this study was done, 4 patients developed arterial hypertension; interestingly, plasma renin activity remained within the normal range. Reduced sodium excretion is suggested as having a pathogenetic role in the hypertension of progressive systemic sclerosis.

References

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Citations

May 1, 1984·The American Journal of Medicine·V D SteenG P Rodnan
Dec 28, 2005·European Journal of Internal Medicine·Mitchell H RosnerMark D Okusa
Jun 1, 1986·International Journal of Dermatology·U F HausteinH J Böhme

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