Functional residual capacity measurement by heptafluoropropane in ventilated newborn lungs: in vitro and in vivo validation

Critical Care Medicine
Hans ProquittéGerd Schmalisch

Abstract

Heptafluoropropane is an inert gas commercially used as propellant for inhalers. Since heptafluoropropane can be detected in low concentrations, it could also be used as a tracer gas to measure functional residual capacity and ventilation homogeneity. The aim of the present study was to validate functional residual capacity measurements by heptafluoropropane wash-in/wash-out (0.8%) during mechanical ventilation in small, surfactant-depleted lungs using a newborn piglet model. Prospective laboratory and animal trial. Animal laboratory in a university setting. Sixteen newborn piglets (age<12 hrs, median weight 1390 g [705-4200 g]) before and after surfactant depletion (Pao2<100 torr in Fio2=1.0) by lung lavage. Heptafluoropropane was measured with a new infrared mainstream sensor connected with the flow sensor of the Dräger Babylog 8000. Accuracy and precision of the measurement technique were tested in a mechanical lung model with a volume range from 11 to 35 mL. Reproducibility of the method and its sensitivity to detect changes of functional residual capacity were assessed in vivo by variation of ventilatory variables. In vitro the absolute error of functional residual capacity was <1 mL (relative errors<3%) with a coefficient...Continue Reading

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Citations

Feb 28, 2014·Pediatric Pulmonology·Anne SchmidtFlorian Singer
Apr 16, 2016·Paediatric Respiratory Reviews·Gerd Schmalisch
Jun 19, 2015·Physiological Measurement·Gerd SchmalischHendrik S Fischer

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