Functional response of cavernosal tissue to distension

Urological Research
G ItalianoF Pagano

Abstract

We studied rabbit isolated erectile tissue responses to changes in preload and to active tension development with norepinephrine. The effects of antagonists of endothelin-1, prostaglandins E2 and F2alpha and of nitric oxide were also tested on normal and de-endothelialized preparations. Tissue distension was found to elicit spontaneous rhythmic contractions. Increase in preload diminished the latency of the spontaneous activity and augmented the developed force. Active tension development and the inhibitor of the Na+,K+ pump, ouabain, opposed the spontaneous activity. A marked reduction in the resting tension with abolition of the spontaneous activity was observed on normal, but not on de-endothelialized tissues, following the addition of the specific prostaglandin E2 and F2alpha receptor antagonist, SC-19220. At 3 x 10(-4) M, the highest concentration used, the endothelin-A receptor antagonist BQ-123 failed to change the pattern of the spontaneous activity and the resting tension of normal tissues. The nitric oxide synthesis inhibitor, L-NAME, did not produce reliable effects. These findings point to a causal relation between cavernosal tissue distension and phasic and tonic contractions. Phasic contractions appear to be elici...Continue Reading

Citations

Jan 5, 2002·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·T F Lue
May 4, 2005·Pharmacology & Therapeutics·Noboru TodaTomio Okamura
Sep 10, 2003·Autonomic Neuroscience : Basic & Clinical·Lars Börjesson, Dick S Delbro
Oct 5, 2012·International Journal of Impotence Research·H NingC-S Lin
Jun 15, 2000·The New England Journal of Medicine·T F Lue
Nov 4, 2009·Journal of the American Society of Hypertension : JASH·Fernando S CarneiroR Clinton Webb

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