Functional response to graded increases in renal nerve activity during hypoxia in conscious rabbits

The American Journal of Physiology
S C MalpasG A Head

Abstract

Changes in renal sympathetic nerve activity (SNA) are postulated to influence renal function in selective ways, such that different levels of activation produce particular renal responses, initially in renin release, then sodium excretion, with changes in renal hemodynamics occurring only with much greater stimulus intensities. The aim of this study was to determine the renal hemodynamic and excretory responses to graded physiological increases in renal SNA induced by breathing different hypoxic gas mixtures. Experiments were performed in seven conscious rabbits subjected to four gas mixtures (14% O2, 10% O2, 10% O2 + 3% CO2, and 10% O2 + 5% CO2) and instrumented for recording of renal nerve activity. After a 30-min control period, rabbits were subjected to one of the four gas mixtures for 30 min, and then room air was resumed for a further 30 min. The four gas mixtures increased renal SNA by 14, 38, 49, and 165% respectively, but arterial pressure (thus renal perfusion pressure) was not altered by any of the gas mixtures. The greatest level of sympathetic activation produced significant falls in glomerular filtration rate (GFR), renal blood flow, sodium and fluid excretion, and significant increases in plasma renin activity. T...Continue Reading

Citations

Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D N MaiorovG A Head
Apr 12, 2001·Journal of Applied Physiology·C HöhneG Kaczmarczyk
Aug 25, 2009·Experimental Physiology·Sarah-Jane GuildSimon C Malpas
Mar 12, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Neeru M SharmaKaushik P Patel
Dec 22, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B L LeonardR G Evans
Oct 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rohit RamchandraSimon C Malpas
Aug 8, 2019·Journal of Neurophysiology·Elizabeth P OttJacqueline K Limberg
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B L LeonardS C Malpas
Jun 12, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kate M DentonWarwick P Anderson
Oct 1, 2020·American Journal of Physiology. Renal Physiology·Andrew R SteeleCraig D Steinback
Feb 6, 2004·Clinical and Experimental Pharmacology & Physiology·Sarah-Jane GuildRoger G Evans
Mar 2, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·C Ichai, C Giunti

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