Functional restoration of exhausted CD4(+) and CD8(+) T cells in chronic viral infection by vinegar-processed flos of Daphne genkwa

Comparative Immunology, Microbiology and Infectious Diseases
Erdenebileg UyangaaSeong Kug Eo

Abstract

T-cell exhaustion has become an important issue in chronic infection because exhausted antigen-specific T cells show impaired abilities to eradicate persistently infected pathogens and produce effector cytokines, such as IFN-γ and TNF-α. Thus, strategies to either restore endogenous exhausted T cell responses or provide functional T cells are needed for therapeutics of chronic infection. Despite promising developments using antibodies and cell immunotherapy, there have been no reported attempts to restore exhausted T cells using treatment with materials derived from natural resources. Here, using a mouse model of chronic infection with lymphocytic choriomeningitis virus (LCMV), we found that vinegar-processed flowers (flos) of Daphne genkwa (vp-genkwa), which was composed mainly of four index components, restored exhausted CD4(+) and CD8(+) T cells significantly, as corroborated by evidence that vp-genkwa treatment enhanced functional LCMV-specific CD4(+) and CD8(+) T cells, both quantitatively and qualitatively. Furthermore, pretreatment with vp-genkwa prevented the generation of exhausted LCMV-specific CD8(+) T cells. Such restorations of exhausted LCMV-specific CD4(+) and CD8(+) T cells by vp-genkwa were closely associated w...Continue Reading

References

Dec 22, 1998·The Journal of Experimental Medicine·A J ZajacR Ahmed
Jul 13, 2004·Science·Joseph N Blattman, Philip D Greenberg
Nov 16, 2005·Nature Immunology·Chen ZhuVijay K Kuchroo
Nov 30, 2006·Annual Review of Immunology·Matthew A Williams, Michael J Bevan
Apr 5, 2007·Nature Protocols·Pratip K ChattopadhyayMario Roederer
Aug 14, 2009·European Journal of Immunology·William D HastingsVijay K Kuchroo
Jun 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R BrahmerSuzanne L Topalian
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hyun-Tak JinRafi Ahmed
Sep 8, 2010·The Journal of Experimental Medicine·Kaori SakuishiAna C Anderson
Mar 3, 2011·Journal of Internal Medicine·K K McKinstryS L Swain
Jul 9, 2011·Nature Immunology·E John Wherry
Aug 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Michael J FullerChristopher M Walker
Nov 26, 2013·Critical Reviews in Immunology·Joseph M KulinskiJames Verbsky

❮ Previous
Next ❯

Related Concepts

Related Feeds

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.