Functional restoration of human immunodeficiency virus and Epstein-Barr virus-specific CD8(+) T cells during highly active antiretroviral therapy is associated with an increase in CD4(+) T cells

European Journal of Immunology
S KostenseDebbie van Baarle

Abstract

To investigate the effect of highly active antiretroviral therapy (HAART) on HIV- and Epstein-Barr virus (EBV)-specific CD8(+) T cells, total number and function of these cells was determined in 16 HIV-infected individuals using tetrameric HLA-peptide complexes and IFN-gamma ELISPOT assays after peptide stimulation, respectively. HAART induced a significant decrease in HIV-specific tetramer(+) T cells, whereas EBV-specific tetramer(+) T cells did not change. In addition, individuals who temporarily failed on therapy showed a temporary increase in the number of HIV-specific T cells, suggesting that differences in the pool size of antigen-specific T cells was determined by the presence of antigen. Interestingly, there was an increase in the ratio of IFN-gamma-producing T cells per total number of both HIV- and EBV-specific T cells in the majority of individuals, suggesting that the function of virus-specific T cells is improved in individuals successfully treated with HAART. Despite this relative functional improvement of EBV-specific T cells, no significant changes were observed in EBV load. In four subjects who temporarily failed on HAART, the percentage of IFN-gamma-producing T cells, both for HIV and EBV, paralleled CD4(+) T ...Continue Reading

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Citations

Dec 15, 2010·Viral Immunology·Ingrid M M SchellensDebbie van Baarle
Nov 6, 2002·The Journal of Clinical Investigation·Sang Kyung LeePremlata Shankar
Dec 9, 2009·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Adyléia A D C ToroMaria Marluce S Vilela
Jun 1, 2006·The Journal of Experimental Medicine·Joseph J MattapallilMario Roederer
Jan 1, 2006·Current Opinion in HIV and AIDS·Joseph J Mattapallil, Mario Roederer
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Nov 2, 2004·Nature Reviews. Cancer·Paolo MoniniBarbara Ensoli
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erwan PiriouDebbie van Baarle
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Insoo KangJoe Craft
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erwan R PiriouDebbie van Baarle

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