Functional RNA structures throughout the Hepatitis C Virus genome

Current Opinion in Virology
Rebecca L AdamsAnna Marie Pyle

Abstract

The single-stranded Hepatitis C Virus (HCV) genome adopts a set of elaborate RNA structures that are involved in every stage of the viral lifecycle. Recent advances in chemical probing, sequencing, and structural biology have facilitated analysis of RNA folding on a genome-wide scale, revealing novel structures and networks of interactions. These studies have underscored the active role played by RNA in every function of HCV and they open the door to new types of RNA-targeted therapeutics.

Citations

Jan 16, 2018·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Anže Lošdorfer BožičLuca Tubiana
Oct 2, 2019·Cold Spring Harbor Perspectives in Medicine·Keisuke TabataRalf Bartenschlager
Oct 17, 2017·Frontiers in Microbiology·Marina Barriocanal, Puri Fortes
Mar 30, 2018·Frontiers in Microbiology·Michael NiepmannOliver Rossbach
Jul 8, 2020·Journal of Biomedical Science·Daniel Sepulveda-CrespoIsidoro Martinez
Aug 22, 2018·Viruses·Annie Bernier, Selena M Sagan
Mar 27, 2019·Expert Reviews in Molecular Medicine·Lucy Rivett, Graeme Alexander
Jun 21, 2020·Vaccines·Daniel Sepulveda-CrespoIsidoro Martinez
Dec 4, 2020·Journal of Virology·Rafael de Cesaris Araujo TavaresAnna Marie Pyle
Apr 4, 2021·Viruses·Hui-Chun LiShih-Yen Lo

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