Functional role and prognostic significance of CD157 in ovarian carcinoma

Journal of the National Cancer Institute
Erika OrtolanAda Funaro

Abstract

CD157, an ADP-ribosyl cyclase-related cell surface molecule, regulates leukocyte diapedesis during inflammation. Because CD157 is expressed in mesothelial cells and diapedesis resembles tumor cell migration, we investigated the role of CD157 in ovarian carcinoma. We assayed surgically obtained ovarian cancer and mesothelial cells and both native and engineered ovarian cancer cell lines for CD157 expression using flow cytometry and reverse transcription-polymerase chain reaction (RT-PCR), and for adhesion to extracellular matrices, migration, and invasion using cell-based assays. We investigated invasion of human peritoneal mesothelial cells by serous ovarian cancer cells with a three-dimensional coculture model. Experiments were performed with or without CD157-blocking antibodies. CD157 expression in tissue sections from ovarian cancer patients (n = 88) was examined by immunohistochemistry, quantified by histological score (H score), and categorized as at or above or below the median value of 60, and compared with clinical parameters. Statistical tests were two-sided. CD157 was expressed by ovarian cancer cells and mesothelium, and it potentiated the adhesion, migration, and invasion of serous ovarian cancer cells through diffe...Continue Reading

References

Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·T KaishoT Hirano
May 9, 1998·Kidney International·B SchröppelD Schlöndorff
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·M RieppiR Giavazzi
May 18, 1999·The American Journal of Pathology·K LessanA P Skubitz
Jun 14, 2000·Chemical Immunology·K Ishihara, T Hirano
May 2, 2001·The Journal of Biological Chemistry·S M EllerbroekM S Stack
Oct 26, 2001·Journal of the Society for Gynecologic Investigation·C A WitzR S Schenken
Dec 6, 2001·The American Journal of Pathology·R C CaseyA P Skubitz
Apr 11, 2002·Nature Cell Biology·Cindy K Miranti, Joan S Brugge
Nov 5, 2002·Cell Biochemistry and Function·Erika OrtolanFabio Malavasi
Mar 15, 2003·Nature Reviews. Cancer·John D Hood, David A Cheresh
May 28, 2003·Biotechnology and Bioengineering·Jens M KelmLars K Nielsen
Feb 18, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Christopher KerfootSusan A Rotenberg
Jun 29, 2004·Journal of Translational Medicine·Ralph S FreedmanEna Wang
Oct 2, 2004·Nature Reviews. Molecular Cell Biology·Wenjun Guo, Filippo G Giancotti
Dec 14, 2004·The New England Journal of Medicine·Stephen A Cannistra
Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·Johanne Leroy-DudalFranck Carreiras
May 3, 2005·Nature Reviews. Cancer·Honami Naora, Denise J Montell
Jul 23, 2005·Clinical & Experimental Metastasis·Kathryn M BurlesonAmy P N Skubitz
Sep 22, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S-K Tay, H Rajesh
Oct 4, 2005·Nature Reviews. Immunology·Marko Salmi, Sirpa Jalkanen
Jan 26, 2006·Journal of Translational Medicine·Kathryn M BurlesonAmy P N Skubitz
Apr 25, 2007·Molecular Carcinogenesis·Magdalena ZietarskaAnne-Marie Mes-Masson
Aug 28, 2007·Cell·Kenneth M Yamada, Edna Cukierman
Jan 16, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles N LandenAnil K Sood
Dec 5, 2008·Molecular Medicine·Alberto L HorensteinFabio Malavasi
Jan 7, 2009·Current Opinion in Obstetrics & Gynecology·Fiona Collinson, Gordon Jayson
Jan 13, 2009·Gynecologic Oncology·Kristy ShieldGregory E Rice
Feb 25, 2009·Nature Reviews. Cancer·Timothy A YapStan B Kaye
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Ada FunaroFabio Malavasi

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Citations

Apr 12, 2011·The Journal of Biological Chemistry·Nicola Lo BuonoAda Funaro
Jul 20, 2010·Journal of the National Cancer Institute·Christina M Annunziata, Michael J Birrer
Nov 9, 2010·Journal of the National Cancer Institute·Erika OrtolanAda Funaro
Apr 12, 2013·Cytometry. Part B, Clinical Cytometry·Valeria QuaronaFabio Malavasi
Apr 29, 2015·Computers in Biology and Medicine·Marco Scianna
Apr 18, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Pooja KhandelwalRebecca A Marsh
May 6, 2014·Frontiers in Behavioral Neuroscience·Olga LopatinaHaruhiro Higashida
Jan 25, 2012·Journal of Biophotonics·Ivana K CecicCalum MacAulay
Jan 26, 2016·Nature Communications·Yiu Huen TsangKenneth L Scott
Apr 23, 2014·The Journal of Biological Chemistry·Simona MoroneAda Funaro
Aug 3, 2011·Journal of Leukocyte Biology·Fabio Malavasi
Mar 28, 2017·BMC Neuroscience·Haruhiro HigashidaOlga Lopatina
May 19, 2017·Frontiers in Behavioral Neuroscience·Satoka KasaiHaruhiro Higashida
Jan 12, 2019·Frontiers in Oncology·Keisuke YakuTakashi Nakagawa

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