PMID: 7523661Jun 1, 1994Paper

Functional role of bicarbonate in propionate transport across guinea-pig isolated caecum and proximal colon

The Journal of Physiology
W von EngelhardtG Rechkemmer

Abstract

1. Unidirectional fluxes of propionate across isolated epithelia from the guinea-pig caecum and proximal colon were measured under short-circuit current conditions. In the caecum and proximal colon the serosal-to-mucosal propionate flux (JPrsm) was higher than mucosal-to-serosal flux (JPrms), resulting in a net secretory flux of propionate. 2. HCO3(-)-CO2-free solution reduced JPrms in the caecum and proximal colon markedly; JPrsm was not (caecum) or little (proximal colon) affected. The subsequent addition of acetazolamide caused a further decrease in JPrms in the proximal colon, but not in the caecum. 3. In HCO3(-)-containing solutions acetazolamide or ethoxzolamide inhibited JPrms; JPrsm was not affected. A macromolecular carbonic anhydrase inhibitor, prontosil-dextran, had no effect on propionate fluxes, indicating that the intracellular carbonic anhydrase is of importance for short-chain fatty acid transport. 4. Subsequent to carbonic anhydrase inhibition, mucosal addition of amiloride caused a slight further decrease of JPrms in the caecum and proximal colon; JPrsm was not affected. 5. Results support the view that a considerable proportion of short-chain fatty acids (SCFAs) is absorbed via a SCFA(-)-HCO3- exchange.

Citations

Jul 20, 2007·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Roger Busche, Wolfgang von Engelhardt
May 23, 1998·The Journal of Physiology·A RitzhauptS P Shirazi-Beechey
Jun 4, 2005·The Journal of Physiology·Volker Endeward, Gerolf Gros
Aug 1, 1997·Kidney International·R M CohenP C Fernandez
Feb 20, 2016·PloS One·Tatiana ShashkovaVadim Govorun
Jan 24, 2007·Pflügers Archiv : European journal of physiology·Koichi KawamataYuichi Suzuki
Jun 1, 1998·The Veterinary Quarterly·W von EngelhardtR Busche
Jan 5, 2002·Physiological Reviews·Karl Kunzelmann, Marcus Mall
Sep 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Martin FoltzHannelore Daniel
Sep 24, 2009·Inflammatory Bowel Diseases·Ronan ThibaultJean-Pierre Segain
Mar 19, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·S TyagiP K Dudeja
Sep 27, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·C HadjiagapiouK Ramaswamy
Nov 1, 1994·Scandinavian Journal of Gastroenterology·S Oltmer, W von Engelhardt
Jan 1, 1995·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·W von EngelhardtG Becker
Apr 8, 1998·The American Journal of Physiology·A N CharneyR W Egnor
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Joseph H. Sellin
Jan 27, 2005·The Journal of Experimental Biology·Tanja KleinkeGerolf Gros
May 19, 2021·Experimental & Molecular Medicine·Jian FangXiaohong Zhang
Sep 27, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Volker EndewardGerolf Gros

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