Functional role of Calcium-stimulated adenylyl cyclase 8 in adaptations to psychological stressors in the mouse: implications for mood disorders

Neuroscience
M RazzoliR Arban

Abstract

The Ca(2+)/calmodulin stimulated adenylyl cylcase 8 (AC8) is a pure Ca(2+) sensor, catalyzing the conversion of ATP to cAMP, with a critical role in neuronal plasticity. A role for AC8 in modulating complex behavioral outcomes has been demonstrated in AC8 knock out (KO) mouse models in which anxiety-like responses were differentially modulated following repeated stress experiences, suggesting an involvement of AC8 in stress adaptation and mood disorders. To further investigate the role of this enzyme in phenotypes relevant for psychiatric conditions, AC8 KO mice were assessed for baseline behavioral and hormonal parameters, responses to repeated restraint stress experience, and long-term effects of chronic social defeat stress. The lack of AC8 conferred a hyperactive-phenotype both in home-cage behaviors and the forced swim test response as well as lower leptin plasma levels and adrenal hypertrophy. AC8 KO mice showed baseline "anxiety" levels similar to wild type littermates in a variety of procedures, but displayed decreased anxiety-like responses following repeated restraint stress. This increased stress resilience was not seen during the chronic social defeat procedure. AC8 KO did not differ from wild type mice in response ...Continue Reading

References

Apr 1, 1978·Physiology & Behavior·D BentonF H Hucklebridge
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L AloeR Levi-Montalcini
Aug 1, 1972·Behavioral Biology·P F Brain
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·Z L WuD R Storm
Jan 15, 1998·The New England Journal of Medicine·B S McEwen
Feb 5, 2003·Neuropsychobiology·Murad AtmacaYilmaz Bayik
Feb 28, 2003·Molecular Pharmacology·Hongbing Wang, Daniel R Storm
Nov 27, 2004·Psychopharmacology·Hubertus HimmerichThomas Pollmächer
Apr 2, 2005·Nature Reviews. Neuroscience·Zhengui Xia, Daniel R Storm
Apr 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·James W MaasLouis J Muglia
Aug 10, 2005·Journal of Neurochemistry·Murat DurakoglugilJenni Harvey
Oct 26, 2005·Biochemical Society Transactions·J HarveyA J Irving
May 10, 2006·Genes, Brain, and Behavior·N SousaC T Wotjak
Jun 21, 2006·Journal of Psychopharmacology·Carmine M Pariante
Jul 15, 2006·Behavioural Brain Research·Jasmine J YapBarry L Jacobs
Jul 27, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Saïd KourrichMark J Thomas
Nov 21, 2007·Current Opinion in Pharmacology·Jenni Harvey
May 2, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ming ZhangHongbing Wang
May 27, 2008·Physiology & Behavior·Scott A RobertsonMartin G Myers
Feb 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Derek P DiRoccoDaniel R Storm
May 2, 2009·Disease Models & Mechanisms·Oz MalkesmanHusseini K Manji
Jun 23, 2009·Psychoneuroendocrinology·Francesca CalabreseMarco A Riva
Aug 21, 2009·Biological Psychiatry·Annetrude J G de Mooij-van MalsenMartien J Kas
Sep 15, 2009·PloS One·Zhenshan WangDaniel R Storm
Mar 6, 2010·Annals of the New York Academy of Sciences·Alan C Swann

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Citations

Oct 18, 2015·Neuroscience and Biobehavioral Reviews·Caroline HammelsBart P F Rutten
Mar 20, 2012·Biological Psychiatry·Boris Tabakoff, Paula L Hoffman
Nov 7, 2014·PloS One·Abhishek Chadha, Boaz Cook
Oct 27, 2021·Physiological Reviews·Katrina F OstromRennolds S Ostrom

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