Functional Role of Transient Receptor Potential Channels in Immune Cells and Epithelia

Frontiers in Immunology
M KhalilM A Engel

Abstract

Transient receptor potential (TRP) ion channels are widely expressed in several tissues throughout the mammalian organism. Originally, TRP channel physiology was focusing on its fundamental meaning in sensory neuronal function. Today, it is known that activation of several TRP ion channels in peptidergic neurons does not only result in neuropeptide release and consecutive neurogenic inflammation. Growing evidence demonstrates functional extra-neuronal TRP channel expression in immune and epithelial cells with important implications for mucosal immunology. TRP channels maintain intracellular calcium homeostasis to regulate various functions in the respective cells such as nociception, production and release of inflammatory mediators, phagocytosis, and cell migration. In this review, we provide an overview about TRP-mediated effects in immune and epithelial cells with an emphasis on mucosal immunology of the gut. Crosstalk between neurons, epithelial cells, and immune cells induced by activation of TRP channels orchestrates the immunologic response. Understanding of its molecular mechanisms paves the way to novel clinical approaches for the treatment of various inflammatory disorders including IBD.

References

Jan 1, 1991·Experimental Lung Research·S L KunkelR M Strieter
Jun 5, 2001·Nature Reviews. Neuroscience·D E ClaphamC Strübing
Mar 15, 2002·Cell·Andrea M PeierArdem Patapoutian
Oct 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wolfgang Liedtke, Jeffrey M Friedman
Feb 18, 2004·British Journal of Pharmacology·Juliano FerreiraJoão B Calixto
Oct 13, 2004·Pulmonary Pharmacology & Therapeutics·Uwe R JuergensHans Vetter
Feb 28, 2006·Cellular Signalling·Alexander StokesHelen Turner
Apr 20, 2006·Biochemical and Biophysical Research Communications·Emmanuelle TixierMichel Neunlist
Jun 30, 2007·American Journal of Respiratory Cell and Molecular Biology·Fabrizio FacchinettiRiccardo Patacchini
Mar 18, 2008·Gastroenterology·Stuart M BrierleyL Ashley Blackshaw
Apr 29, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ashwini S SabnisGarold S Yost
Jun 22, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kazutoshi HamanakaJames C Parker
Jul 19, 2011·Gastroenterology·Matthias A EngelPeter W Reeh
May 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth S FernandesSusan D Brain
Apr 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Rithwik RamachandranMorley D Hollenberg
Jul 25, 2015·PloS One·Sonja M Mueller-TribbenseeMatthias A Engel
Nov 26, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachel G ScheragaMitchell A Olman
Jun 18, 2016·International Journal of Biological Sciences·Jin-Feng ZhaoTzong-Shyuan Lee
Aug 9, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Clémence O HenryMustapha Si-Tahar
Apr 26, 2017·Proceedings of the National Academy of Sciences of the United States of America·Nandini AcharyaPramod K Srivastava

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Citations

May 19, 2018·Pharmaceuticals·Benedikt FelsAlbrecht Schwab
Nov 18, 2018·The Journal of Pharmacology and Experimental Therapeutics·Raziye MohammadpourHamidreza Ghandehari
Mar 3, 2020·Frontiers in Immunology·Frank H Robledo-AvilaSantiago Partida-Sánchez
Mar 11, 2020·Frontiers in Immunology·Yiding ChenHu Zhang
May 16, 2020·Frontiers in Immunology·Dennis ClementKarl-Johan Malmberg
Mar 19, 2020·International Journal of Molecular Sciences·Paulina StokłosaChristine Peinelt
Aug 14, 2019·Immunological Reviews·Trisha Mahtani, Bebhinn Treanor
Dec 27, 2019·International Immunopharmacology·Lucia Malaguarnera
Feb 16, 2021·Neuroscience Letters·Qihai Gu, Lu-Yuan Lee
Jan 29, 2021·Journal of Ethnopharmacology·Guilherme Venâncio SímaroJairo Kenupp Bastos
Nov 17, 2020·Frontiers in Immunology·Harold A SilvermanEric H Chang
Mar 9, 2021·Frontiers in Medicine·Aylin RuppensteinUlrike Raap
Mar 20, 2021·Current Allergy and Asthma Reports·Wout BackaertLaura Van Gerven
Sep 8, 2020·Seminars in Pediatric Neurology·Mojdeh Mostafavi, John Gaitanis
Apr 4, 2021·International Journal of Molecular Sciences·Joanna K BujakPiotr Bednarczyk
Jun 10, 2019·Cell Calcium·Chloé GrebertClarisse Vandebrouck
Jul 6, 2021·Frontiers in Immunology·Joana P FirminoEnric Gisbert
Aug 28, 2021·International Journal of Molecular Sciences·Sachiko KoyamaThomas Heinbockel
Sep 25, 2021·Journal of Biochemistry·Naoya TobitaTakeshi Yamamoto

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Methods Mentioned

BETA
bronchoalveolar lavage

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