Functional roles and potential clinical application of miRNA-345-5p in prostate cancer

The Prostate
I TinayLi Jia

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs, which negatively regulate gene expression and impact prostate cancer (PCa) growth and progression. Circulating miRNAs are stable and detectable in cell-free body fluids, such as serum. Investigation of circulating miRNAs presents great potential in uncovering new insights into the roles of miRNAs in PCa diagnosis and therapy. Using TaqMan miRNA quantitative reverse transcription polymerase chain reaction (RT-qPCR), we compared the expression levels of five miRNAs (miR-193a-3p, miR-9-3p, miR-335-5p, miR-330-3p, and miR-345-5p) in serum samples from 20 normal individuals without cancer, 25 patients with localized disease, 25 patients with hormone-naïve or hormone sensitive metastatic disease, and 25 patients with metastatic castration-resistant prostate cancer (CRPC). These five miRNAs were identified as potential oncogenes in our previous studies. MiR-345-5p was further investigated for its functional roles in CRPC cells. We discovered that miR-9-3p, miR-330-3p-3p, and miR-345-5p were significantly overexpressed in serum from PCa patients when compared to serum from individuals without cancer. No differential expression patterns were observed between different disease categories. How...Continue Reading

References

Feb 4, 2003·American Journal of Human Genetics·S L SlagerS N Thibodeau
Oct 27, 2004·PLoS Biology·Bino JohnDebora S Marks
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Jan C BraseHolger Sültmann
Jun 29, 2010·Cancer Cell·Barry S TaylorWilliam L Gerald
Nov 5, 2011·International Journal of Cancer. Journal International Du Cancer·Luke A SelthLisa M Butler
Jan 14, 2012·British Journal of Cancer·R J BryantF C Hamdy
Jan 23, 2013·Biochemical and Biophysical Research Communications·Yuefeng LiJinchuan Yan
Feb 7, 2013·Molecular Cancer Research : MCR·Dali ZhengLi Jia
Mar 27, 2013·Molecular and Cellular Biology·Jon S ZawistowskiGary L Johnson
Sep 16, 2014·Advanced Drug Delivery Reviews·Guofeng Cheng
Nov 8, 2014·Nucleic Acids Research·Nathan Wong, Xiaowei Wang
Aug 1, 2015·Journal of Cancer Research and Clinical Oncology·Qi-guang ChenChui-ze Kong
Aug 13, 2015·ELife·Vikram AgarwalDavid P Bartel
Jul 30, 2016·Cancer Letters·Rajbir SinghArnab Chakravarti
Nov 3, 2016·Nature Reviews. Urology·Annika FendlerKlaus Jung
Apr 19, 2017·British Journal of Cancer·Aruz MesciStanley K Liu
Dec 12, 2017·The Prostate·Agnieszka PaziewskaJerzy Ostrowski
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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Citations

Nov 17, 2019·International Journal of Molecular Sciences·Elena PiccininAntonio Moschetta
Jan 31, 2019·Diagnostics·Jochen Neuhaus, Bo Yang
Aug 17, 2019·Cancers·Bahar Shamloo, Sinem Usluer
Aug 28, 2020·Frontiers in Genetics·Beenish RahatJyotdeep Kaur
Dec 29, 2020·Cancer Biomarkers : Section a of Disease Markers·Angelika TölleCarsten Stephan
Mar 24, 2021·Prostate Cancer and Prostatic Diseases·Ozel CapikOmer Faruk Karatas
Apr 4, 2021·Pharmaceutics·Noemi Arrighetti, Giovanni Luca Beretta
Jun 30, 2021·Molecular Cancer Research : MCR·Weijing LiuWeipeng Liu
Jul 8, 2021·Anti-cancer Drugs·Nesil Yalman

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