Functional roles of bladder α1-adrenoceptors in the activation of single-unit primary bladder afferent activity in rats

BJU International
Naoki AizawaYasuhiko Igawa

Abstract

To clarify the involvement of bladder α1-adrenoceptors (α1-ARs) in afferent pathways by investigating the effects of silodosin and BMY7378, selective α1A- or α1D-AR antagonists, respectively, on single-unit afferent nerve fibre activity (SAA) of the primary bladder afferent nerves and their relationship with bladder microcontractions in rats. A total of 63 female Sprague-Dawley rats were anaesthetized with urethane. The SAA of Aδ and C fibres generated from the left L6 dorsal roots was determined using electrical stimulation of the left pelvic nerve and bladder distension. After measuring baseline SAA during constant filling cystometry, the procedure was repeated with i.v. (0.3-30 μg/kg) or intravesical (10 μm) administration of each antagonist. In separate rats, the bladder was filled with saline until the intravesical pressure reached 30 cmH2 O, and was kept under isovolumetric conditions, then the recording was performed with i.v.-administered vehicle and silodosin (0.3 μg/kg). A total of Aδ fibres and 33 C fibres were isolated from 63 rats. The SAA of Aδ fibres, but not C fibres, were dose-dependently decreased after both i.v. and intravesical administrations of each of the antagonists. In the experiments under bladder isov...Continue Reading

References

Dec 22, 1999·Neurourology and Urodynamics·S Matsuura, J W Downie
Nov 30, 2000·Scandinavian Journal of Urology and Nephrology·M C MonneronP Alberts
Jan 29, 2002·Anesthesia and Analgesia·Koji Hara, R Adron Harris
Feb 22, 2002·Neurourology and Urodynamics·Paul AbramsUNKNOWN Standardisation Sub-committee of the International Continence Society
Jan 13, 2006·The Journal of Urology·Hiroko IshihamaMasahito Kawatani
Feb 2, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Satoru TakahashiTadaichi Kitamura
Jun 17, 2008·Urology·J Kellogg ParsonsElizabeth Barrett-Connor
Nov 11, 2008·Biomedical Research·Haruko YanaseMasahito Kawatani
Aug 6, 2009·Handbook of Experimental Pharmacology·William C de Groat, Naoki Yoshimura
Dec 22, 2009·Neurourology and Urodynamics·L BirderM Drake
Oct 22, 2010·Scandinavian Journal of Urology and Nephrology·Yoshiki KurizakiKarl-Erik Andersson
Nov 1, 2011·Neurourology and Urodynamics·Naoki AizawaYasuhiko Igawa
Nov 5, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Yukio HommaUNKNOWN Japanese Urological Association
Dec 1, 2012·American Journal of Physiology. Renal Physiology·Mitsuharu YoshiyamaWilliam C de Groat
Dec 21, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Toshiro ShirakawaMasato Fujisawa
Apr 17, 2013·Physiological Reviews·Lori Birder, Karl-Erik Andersson
Jun 5, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Kenya YamaguchiSatoru Takahashi
Jan 1, 2014·Neurourology and Urodynamics·Takahiro YamagishiKarl-Erik Andersson
Jan 20, 2015·BJU International·Marc P SchneiderThomas M Kessler

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Citations

Jan 17, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoshiki NagaoMotoaki Saito
Nov 19, 2019·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Naoki Aizawa
Jul 12, 2018·International Neurourology Journal·Hsi-Hsien ChangStephen Shei-Dei Yang

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