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Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes

Circulation Research

Nov 20, 2019

Zhifen ChenChad A Cowan

Abstract

Rationale: Genome-wide association studies (GWAS) have identified genetic loci associated with insulin resistance (IR) but pinpointing the causal genes of a risk locus has been challenging. Objective: To identify candidate causal genes for IR, we screened regional and biologically plaus...read more

Mentioned in this Paper

Genome-Wide Association Study
Diabetes Mellitus, Non-Insulin-Dependent
Study
GPC3
Insulin Sensitivity
Genes
CRISPR-Cas Systems
GRB14 gene
Knock-out
Candidate Disease Gene
1
2
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Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes

Circulation Research

Nov 20, 2019

Zhifen ChenChad A Cowan

PMID: 31739742

DOI: 10.1161/circresaha.119.315246

Abstract

Rationale: Genome-wide association studies (GWAS) have identified genetic loci associated with insulin resistance (IR) but pinpointing the causal genes of a risk locus has been challenging. Objective: To identify candidate causal genes for IR, we screened regional and biologically plaus...read more

Mentioned in this Paper

Genome-Wide Association Study
Diabetes Mellitus, Non-Insulin-Dependent
Study
GPC3
Insulin Sensitivity
Genes
CRISPR-Cas Systems
GRB14 gene
Knock-out
Candidate Disease Gene
1
2

Similar Papers Found In These Feeds

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