Functional significance of lymphocytes in pregnancy and lymphocyte immunotherapy in infertility: A comprehensive review and update.

International Immunopharmacology
Roghayeh JafarpourMorteza Motallebnezhad

Abstract

During pregnancy, the fetal-maternal interface underlies several dynamic alterations to permit the fetus to be cultivated and developed in the uterus, in spite of being identifies by the maternal immune system. A large variety of decidual leukocyte populations, including natural killer cells, NKT cells, innate lymphoid cells, dendritic cells, B cells, T cells, subpopulations of helper T cells play a vital role in controlling the trophoblast invasion, angiogenesis as well as vascular remodeling. In contrast, several regulatory immunosuppressive mechanisms, including regulatory T cells, regulatory B cells, several cytokines and mediators are involved in maintain the homeostasis of immune system in the fetal-maternal interface. Nonetheless, aberrant alterations in the balance of immune inflammatory or immunosuppressive arms have been associated with various pregnancy losses and infertilities. As a result, numerous strategies have been developed to revers dysregulated balance of immune players to increase the chance of successful pregnancy. Lymphocyte immunotherapy has been developed through utilization of peripheral white blood cells of the husband or others and administered into the mother to confer an immune tolerance for embryo...Continue Reading

References

Jan 1, 1977·Vitamins and Hormones·M Levitz, B K Young
Dec 1, 1995·The Journal of Experimental Medicine·A Bendelac
Jan 1, 1995·Journal of Reproductive Immunology·N M BhatN N Teng
Oct 1, 1995·The Journal of Experimental Medicine·S CardellD Mathis
Jul 1, 1994·Human Reproduction·M T IlleniE Radici
Aug 1, 1996·The Journal of Experimental Medicine·I RothS J Fisher
Nov 1, 1996·Biology of Reproduction·N Vassiliadou, J N Bulmer
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·T KawanoM Taniguchi
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·K ItoM Taniguchi
Nov 4, 2000·International Archives of Allergy and Immunology·G B DealtryN Fernandez
Dec 5, 2000·Current Opinion in Immunology·O ThellinE Heinen
Jul 4, 2001·American Journal of Reproductive Immunology : AJRI·H TsudaS Saito
Jul 5, 2001·Journal of Reproductive Immunology·L SvenssonR Mattsson
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C M GrimaldiB Diamond
Oct 20, 2001·American Journal of Reproductive Immunology : AJRI·C L ElliottM H Sullivan
Jun 1, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dorota Darmochwal-KolarzJan Oleszczuk
Jul 27, 2002·Cellular Immunology·Sen WangToru Abo
Aug 3, 2002·Nature Reviews. Immunology·Mitchell Kronenberg, Laurent Gapin
Sep 5, 2002·Nature Reviews. Immunology·Ashley Moffett-King
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jonathan E BoysonJack L Strominger
Jan 9, 2003·American Journal of Reproductive Immunology : AJRI·Ana C ZenclussenPetra C Arck
Jan 9, 2003·American Journal of Reproductive Immunology : AJRI·Barbara JablonowskaJan Ernerudh
Jan 9, 2003·American Journal of Reproductive Immunology : AJRI·Andrea CanelladaRicardo A Margni Idehu
Jan 16, 2003·Immunology Letters·Woon Ling ChanHamish Hamilton
Jul 12, 2003·American Journal of Reproductive Immunology : AJRI·A Sindram-TrujilloF Claas
Oct 28, 2003·Nature Immunology·Francesca FallarinoPaolo Puccetti
Dec 4, 2003·Archives of Gynecology and Obstetrics·Manoj Kumar PandeySuraksha Agrawal
Dec 16, 2003·American Journal of Reproductive Immunology : AJRI·Shigeki ShimadaHideto Yamada
Feb 6, 2004·Nature Immunology·Varuna R AluvihareAlexander G Betz

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Nov 20, 2020·Clinical & Translational Immunology·Stefano SotgiuAlessandra Carta

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