Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments

Journal of Cardiovascular Development and Disease
Sofya Pozdniakova, Yury Ladilov

Abstract

Mounting evidence confirms the compartmentalized structure of evolutionarily conserved 3'⁻5'-cyclic adenosine monophosphate (cAMP) signaling, which allows for simultaneous participation in a wide variety of physiological functions and ensures specificity, selectivity and signal strength. One important player in cAMP signaling is soluble adenylyl cyclase (sAC). The intracellular localization of sAC allows for the formation of unique intracellular cAMP microdomains that control various physiological and pathological processes. This review is focused on the functional role of sAC-produced cAMP. In particular, we examine the role of sAC-cAMP in different cellular compartments, such as cytosol, nucleus and mitochondria.

References

Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·J BuckL R Levin
Jun 21, 2002·Trends in Cell Biology·Philip J S Stork, John M Schmitt
Jun 28, 2002·Physiological Reviews·U Benjamin Kaupp, Reinhard Seifert
Dec 12, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jonathan H ZippinJochen Buck
Mar 1, 2003·The Journal of Biological Chemistry·Tatiana N LitvinLonny R Levin
Sep 30, 2003·Nature Cell Biology·Xiao Fei WangHsiao Chang Chan
Feb 11, 2004·The Journal of Cell Biology·Jonathan H ZippinJochen Buck
Feb 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Gloria EspositoByjay S Jaiswal
Jun 2, 2004·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Masayuki Ohmori, Shinobu Okamoto
Nov 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Lisa M DiPilatoJin Zhang
Jan 22, 2005·American Journal of Physiology. Cell Physiology·Weidong GengOrson W Moe
Jun 17, 2005·American Journal of Physiology. Cell Physiology·Yan WangPingbo Huang
Jul 27, 2005·The Journal of Experimental Medicine·Hyunsil HanCarl Nathan
Oct 27, 2005·Molecular Reproduction and Development·James A ChaloupkaJochen Buck
Apr 22, 2006·The Journal of Biological Chemistry·Alexander M StessinLonny R Levin
Aug 29, 2006·Journal of Molecular Biology·Margarita KamenetskyClemens Steegborn
Sep 12, 2006·Nature Neuroscience·Karen Y WuSamie R Jaffrey
Sep 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Zhidan WuSusan C Stevenson
Oct 14, 2006·Circulation Research·Rodolphe FischmeisterGrégoire Vandecasteele
May 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Wen Ming XuHsiao Chang Chan
Dec 28, 2007·American Journal of Physiology. Cell Physiology·Núria M Pastor-SolerSylvie Breton
Aug 13, 2008·The Journal of General Physiology·Lavoisier S RamosLonny R Levin
Mar 4, 2009·Cell Metabolism·Rebeca Acin-PerezGiovanni Manfredi
Apr 2, 2009·The Journal of Biological Chemistry·Sanjeev KumarYury Ladilov
Apr 2, 2009·Nature Reviews. Drug Discovery·Sandra PierreKlaus Scholich
Feb 12, 2010·American Journal of Physiology. Renal Physiology·Fan GongNúria M Pastor-Soler
Apr 13, 2010·Journal of the American Chemical Society·Richard S AgnesDavid S Lawrence
Apr 15, 2011·Kidney International·Martin TresguerresJochen Buck
Jul 5, 2011·The Journal of Biological Chemistry·Rebeca Acin-PerezClemens Steegborn
Sep 6, 2011·Journal of Molecular and Cellular Cardiology·Delphine MikaRodolphe Fischmeister
Oct 14, 2011·The Journal of Biological Chemistry·Yong S LeeAlan D Marmorstein
Nov 23, 2011·Archives of Dermatology·Cynthia M MagroJonathan H Zippin

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Citations

Jul 28, 2018·British Journal of Pharmacology·Sofya PozdniakovaVera Regitz-Zagrosek
Aug 29, 2020·Cells·Karina FormosoJeanne Mialet-Perez
Aug 29, 2020·Cells·Muhammad Aslam, Yury Ladilov
Sep 1, 2021·Proceedings of the National Academy of Sciences of the United States of America·Sunil KrishnaPraveen Ballabh
Sep 3, 2021·Cell Death & Disease·Marion LaudetteFrank Lezoualc'h

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