Abstract
VEGF is one of the key factors in tumor angiogenesis that may be involved in tumor growth and metastasis. VEGF receptor, a naturally occurring soluble form of the VEGFR-1 (sVEGFR-1. flt-1), is produced by endothelial cells by differential splicing of the flt-1 gene, and is a negative counterpart of the VEGF signaling pathway. We investigated the levels of VEGF and sVEGFR-1, a known intrinsic inhibitor of VEGF, in 42 patients with various types of lung cancers before beginning treatment and 18 healthy subjects. Serum sVEGFR-1 levels (mean +/- SD; pg/ml) were 465.17 +/- 158.34 in patients and were significantly higher than those of the healthy subjects (156.39 +/- 89.17) (P < 0.0001). Serum VEGF levels of patients (449.48 +/- 175.54 pg/ml) were significantly higher in patients than in healthy subjects (77.06 +/- 47.26 pg/ml) (P < 0.0001). We conclude that increased sVEGFR-1 and VEGF levels are important parameters in lung cancers.
References
Feb 21, 1992·Science·C de VriesL T Williams
Sep 30, 1992·Biochemical and Biophysical Research Communications·B I TermanP Böhlen
Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Nov 1, 1989·Disease-a-month : DM·R A Johnson, G D Roodman
Dec 28, 1995·The New England Journal of Medicine·J Folkman
Jul 26, 1996·The Journal of Biological Chemistry·M ClaussW Risau
Aug 9, 1996·Cell·D Hanahan, J Folkman
Sep 13, 1996·Biochemical and Biophysical Research Communications·R L KendallK A Thomas
Oct 1, 1996·Cytokine & Growth Factor Reviews·M Klagsbrun, P A D'Amore
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·R MöhleS Rafii
Jun 1, 1997·Chest·C F Mountain
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·M G AchenS A Stacker
Apr 7, 1998·Cell·S SokerM Klagsbrun
Dec 16, 1998·Lancet·H M PinedoJ Folkman
May 8, 1999·Lancet·K J O'ByrneA L Harris
Jun 9, 1999·British Journal of Cancer·R SalgadoL Y Dirix
Jul 20, 1999·Journal of Immunological Methods·C HornigH A Weich
Apr 5, 2000·The Journal of Biological Chemistry·D WangR S Warren
Sep 13, 2001·The Journal of Biological Chemistry·J F WangJ E Groopman
May 15, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y D JungL M Ellis
Citations
Jun 25, 2009·Surgical Endoscopy·H M C Shantha KumaraR L Whelan
Apr 22, 2009·Medical Oncology·Francisco Javier Gonzalez BarcalaLuis Valdes Cuadrado
Sep 9, 2008·Archivos de bronconeumología·Esther Barreiro
Oct 11, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yi JingBing-Hua Jiang
Oct 19, 2006·Respiratory Research·Andriana I PapaioannouKonstantinos I Gourgoulianis
Sep 22, 2010·Growth Factors·Przemyslaw PrzewratilEwa Andrzejewska
Oct 17, 2014·Experimental Lung Research·Alba Miranda-RiberaSimeon E Goldblum
Jul 31, 2007·Cancer Investigation·A YilmaztepeA Tokullugil
Mar 28, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Magdalena BieniaszJanusz Szemraj
Nov 14, 2007·American Journal of Reproductive Immunology : AJRI·Si Hyun ChoByung Seok Lee
Jan 12, 2007·Cancer Science·Tatsuro YamaguchiMasakazu Toi
Jan 11, 2012·Microvascular Research·SiHyun ChoByung Seok Lee
Feb 5, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A Katsabeki-KatsafliK I Gourgoulianis
Feb 18, 2017·International Journal of Molecular Sciences·Cherine Abou-FayçalBeatrice Eymin
Sep 8, 2015·International Journal of Environmental Research and Public Health·Fuhong LiuJu Liu
Oct 25, 2011·Cell Communication & Adhesion·David Bruce, Peng H Tan
Jul 31, 2008·Pancreas·Yu-Ting ChangJau-Min Wong
Apr 28, 2006·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chunyan LiXueying Sun
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Chao CaoZai-Chun Deng
Feb 12, 2020·The Journal of Dermatological Treatment·Erhan AyhanEşref Araç
Jan 25, 2019·Scientific Reports·Cherine Abou FaycalBeatrice Eymin
Mar 31, 2019·Cells·Megan Stevens, Sebastian Oltean
May 18, 2021·Revista Española De Medicina Nuclear E Imagen Molecular·M C Pombo PasínA Ruibal Morell