Functional significance of vascular endothelial growth factor and its receptor (receptor-1) in various lung cancer types

Clinical Biochemistry
Nevin IlhanFigen Deveci

Abstract

VEGF is one of the key factors in tumor angiogenesis that may be involved in tumor growth and metastasis. VEGF receptor, a naturally occurring soluble form of the VEGFR-1 (sVEGFR-1. flt-1), is produced by endothelial cells by differential splicing of the flt-1 gene, and is a negative counterpart of the VEGF signaling pathway. We investigated the levels of VEGF and sVEGFR-1, a known intrinsic inhibitor of VEGF, in 42 patients with various types of lung cancers before beginning treatment and 18 healthy subjects. Serum sVEGFR-1 levels (mean +/- SD; pg/ml) were 465.17 +/- 158.34 in patients and were significantly higher than those of the healthy subjects (156.39 +/- 89.17) (P < 0.0001). Serum VEGF levels of patients (449.48 +/- 175.54 pg/ml) were significantly higher in patients than in healthy subjects (77.06 +/- 47.26 pg/ml) (P < 0.0001). We conclude that increased sVEGFR-1 and VEGF levels are important parameters in lung cancers.

References

Sep 30, 1992·Biochemical and Biophysical Research Communications·B I TermanP Böhlen
Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Nov 1, 1989·Disease-a-month : DM·R A Johnson, G D Roodman
Oct 1, 1996·Cytokine & Growth Factor Reviews·M Klagsbrun, P A D'Amore
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·R MöhleS Rafii
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·M G AchenS A Stacker
Dec 16, 1998·Lancet·H M PinedoJ Folkman
May 15, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y D JungL M Ellis

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Citations

Apr 22, 2009·Medical Oncology·Francisco Javier Gonzalez BarcalaLuis Valdes Cuadrado
Sep 9, 2008·Archivos de bronconeumología·Esther Barreiro
Oct 11, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yi JingBing-Hua Jiang
Oct 19, 2006·Respiratory Research·Andriana I PapaioannouKonstantinos I Gourgoulianis
Sep 22, 2010·Growth Factors·Przemyslaw PrzewratilEwa Andrzejewska
Oct 17, 2014·Experimental Lung Research·Alba Miranda-RiberaSimeon E Goldblum
Mar 28, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Magdalena BieniaszJanusz Szemraj
Nov 14, 2007·American Journal of Reproductive Immunology : AJRI·Si Hyun ChoByung Seok Lee
Feb 5, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A Katsabeki-KatsafliK I Gourgoulianis
Feb 18, 2017·International Journal of Molecular Sciences·Cherine Abou-FayçalBeatrice Eymin
Sep 8, 2015·International Journal of Environmental Research and Public Health·Fuhong LiuJu Liu
Apr 28, 2006·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chunyan LiXueying Sun
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Chao CaoZai-Chun Deng
Jan 25, 2019·Scientific Reports·Cherine Abou FaycalBeatrice Eymin

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