Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva.

Cell Reports
M. SaitouOmer Gokcumen

Abstract

Salivary proteins are essential for maintaining health in the oral cavity and proximal digestive tract, and they serve as potential diagnostic markers for monitoring human health and disease. However, their precise organ origins remain unclear. Through transcriptomic analysis of major adult and fetal salivary glands and integration with the saliva proteome, the blood plasma proteome, and transcriptomes of 28+ organs, we link human saliva proteins to their source, identify salivary-gland-specific genes, and uncover fetal- and adult-specific gene repertoires. Our results also provide insights into the degree of gene retention during gland maturation and suggest that functional diversity among adult gland types is driven by specific dosage combinations of hundreds of transcriptional regulators rather than by a few gland-specific factors. Finally, we demonstrate the heterogeneity of the human acinar cell lineage. Our results pave the way for future investigations into glandular biology and pathology, as well as saliva's use as a diagnostic fluid.

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Citations

May 13, 2021·Journal of Dental Research·C GluckR A Romano
May 26, 2021·Journal of Dental Research·W W LauS Ruhl
Jun 19, 2021·The Journal of Prosthetic Dentistry·Hitoshi Uchida, Catherine E Ovitt

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Datasets Mentioned

BETA
GSE143702

Methods Mentioned

BETA
FCGBP
glycosylation
RNA-seq
periodic acid Schiff
electrophoresis
biopsies
RNaseq
biopsy
protein assay

Software Mentioned

DESeq
Ensembl
Kallisto
Rstudio
DESeq2
biomaRt
R base package
R
RNaseq
MultiQC

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