PMID: 7014975Mar 1, 1981Paper

Functional state of the renin-angiotensin system in the diuretic therapy of hypertension

Kardiologiia
A A Nekrasova, T K Mergenbaeva

Abstract

The functional condition of the renin-angiotensin system (RAS) was studied according to the level of plasma-renin activity determined under basal conditions and after walking prior to and after 3 days of medication with furosemide and after a course of hydrochlorothiazide treatment. The authors studied 34 males from 22 to 45 years of age with an uncomplicated course of hypertensive disease and labile or stable hypertension. Three groups of patients were distinguished according to the reaction of renin activity to walking in the control period: I, normorenin with normal basal level of renin activity, a somewhat reduced but within normal ranges and gradually growing during treatment RAS reaction; II, hyperrenin with a higher basal level of renin activity which increased sharply after stimulation by walking and furosemide; III, hyporenin with a very low basal level of renin activity which was areactive to stimulation by walking and hyporeactive to stimulation by furosemide. The hypotensive effect of diuretics was higher in patients of group II. In group III patients there was a prevalent decrease in sytolic arterial pressure. No connection was found between the decrease in arterial pressure and the decrease in the volume of circul...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.