Functional Strength Training and Movement Performance Therapy for Upper Limb Recovery Early Poststroke-Efficacy, Neural Correlates, Predictive Markers, and Cost-Effectiveness: FAST-INdiCATE Trial

Frontiers in Neurology
Susan M HunterValerie Pomeroy

Abstract

Variation in physiological deficits underlying upper limb paresis after stroke could influence how people recover and to which physical therapy they best respond. To determine whether functional strength training (FST) improves upper limb recovery more than movement performance therapy (MPT). To identify: (a) neural correlates of response and (b) whether pre-intervention neural characteristics predict response. Explanatory investigations within a randomised, controlled, observer-blind, and multicentre trial. Randomisation was computer-generated and concealed by an independent facility until baseline measures were completed. Primary time point was outcome, after the 6-week intervention phase. Follow-up was at 6 months after stroke. With some voluntary muscle contraction in the paretic upper limb, not full dexterity, when recruited up to 60 days after an anterior cerebral circulation territory stroke. Conventional physical therapy (CPT) plus either MPT or FST for up to 90 min-a-day, 5 days-a-week for 6 weeks. FST was "hands-off" progressive resistive exercise cemented into functional task training. MPT was "hands-on" sensory/facilitation techniques for smooth and accurate movement. The primary efficacy measure was the Action Rese...Continue Reading

References

Jan 1, 1980·European Neurology·G DemeurisseE Robaye
Apr 1, 1997·Stroke; a Journal of Cerebral Circulation·C M Dean, R B Shepherd
Nov 21, 1997·Medical Care·P Dolan
May 5, 1998·Medical Decision Making : an International Journal of the Society for Medical Decision Making·A A Stinnett, J Mullahy
Jun 6, 1996·Health Policy·R Brooks
Mar 11, 2000·Lancet·V M Pomeroy, R C Tallis
Jun 2, 2001·Stroke; a Journal of Cerebral Circulation·E S LawrenceC D Wolfe
Jun 2, 2001·Archives of Physical Medicine and Rehabilitation·D M MorrisE Taub
Jul 7, 2001·Stroke; a Journal of Cerebral Circulation·S L WolfA Piacentino
Mar 19, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Fumiko MaedaAlvaro Pascual-Leone
Jul 20, 2002·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·Susan E FasoliMieke H Verfaellie
Jul 23, 2003·American Journal of Physical Medicine & Rehabilitation·John Whyte, Tessa Hart
Aug 21, 2003·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Andrew H BriggsMartin J Price
Aug 26, 2003·Brain : a Journal of Neurology·N S WardR S J Frackowiak
Oct 7, 2003·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·Kimatha Oxford GriceMary Ann Vollmer
Mar 30, 2004·Trends in Neurosciences·Silvia Arber
May 6, 2004·Health Economics·Elisabeth FenwickAndrew Briggs
Jun 2, 2005·Journal of Neuroengineering and Rehabilitation·Andrew J ButlerPaul Weiss
Jan 20, 2006·Brain : a Journal of Neurology·Nick S WardRichard S J Frackowiak
May 17, 2006·Brain : a Journal of Neurology·Jennifer M NewtonRichard S J Frackowiak
Aug 29, 2006·Archives of Physical Medicine and Rehabilitation·Derek G KamperWilliam Z Rymer
Nov 2, 2006·JAMA : the Journal of the American Medical Association·Steven L WolfUNKNOWN EXCITE Investigators
Nov 3, 2006·Physical Therapy·Sarah BlantonSteven L Wolf
Nov 30, 2006·The Australian Journal of Physiotherapy·Louise AdaColleen G Canning
Dec 7, 2006·Brain : a Journal of Neurology·Cathy M StinearWinston D Byblow
Dec 19, 2006·Neurorehabilitation and Neural Repair·Corwin BoakeHarvey S Levin
Dec 21, 2006·Physical Therapy·Jocelyn E Harris, Janice J Eng
Aug 21, 2007·Neurorehabilitation and Neural Repair·Nuray YozbatiranSteven C Cramer
Sep 19, 2007·Neurorehabilitation and Neural Repair·Geert VerheydenWilly De Weerdt
Oct 19, 2007·The Cochrane Database of Systematic Reviews·B FrenchC L Watkins
Sep 17, 2008·Neurorehabilitation and Neural Repair·Annette A van KuijkAlexander C H Geurts
Oct 1, 2008·BMJ : British Medical Journal·Peter CraigUNKNOWN Medical Research Council Guidance
Oct 22, 2008·Archives of Physical Medicine and Rehabilitation·Susan M HunterValerie M Pomeroy
Feb 5, 2009·Neurorehabilitation and Neural Repair·UNKNOWN Cumberland Consensus Working GroupSteven Wolf
Feb 26, 2009·Neurorehabilitation and Neural Repair·Bruce H Dobkin
Oct 6, 2009·Archives of Physical Medicine and Rehabilitation·Catherine E LangPatricia L Scheets

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Citations

Jan 9, 2019·Disability and Rehabilitation·Stanley WinserPriya Kannan
Mar 21, 2020·The Cochrane Database of Systematic Reviews·David H SaundersGillian E Mead
Mar 7, 2021·Brain Sciences·David García-ÁlvarezRaquel Faubel

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Clinical Trials Mentioned

ISRCTN19090862

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Digitimer Neurolog
FMRIB Software Library ( FSL
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CONSORT
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