Functional structure of the mitral cell dendritic tuft in the rat olfactory bulb.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Maja DjurisićDejan Zecevic

Abstract

The input-output transform performed by mitral cells, the principal projection neurons of the olfactory bulb, is one of the key factors in understanding olfaction. We used combined calcium and voltage imaging from the same neuron and computer modeling to investigate signal processing in the mitral cells, focusing on the glomerular dendritic tuft. The main finding was that the dendritic tuft functions as a single electrical compartment for subthreshold signals within the range of amplitudes detectable by voltage-sensitive dye recording. These evoked EPSPs had uniform characteristics throughout the glomerular tuft. The Ca(2+) transients associated with spatially uniform subthreshold synaptic potentials were comparable but not equal in amplitude in all regions. The average range of normalized amplitudes of the EPSP-driven Ca(2+) signals from different locations on dendritic branches in the glomerular tuft was relatively narrow and appeared to be independent of the dendritic surface-to-volume ratio. The computer simulations constrained by the imaging data indicated that a synchronized activation of approximately 100 synapses randomly distributed on tuft branches was sufficient to generate spatially homogenous EPSPs. This number of ...Continue Reading

Citations

Aug 4, 2009·Journal of Computational Neuroscience·Liam PaninskiWei Wu
Nov 28, 2009·Journal of Computational Neuroscience·Liam Paninski
Aug 24, 2011·Journal of Computational Neuroscience·Jonathan Hunter Huggins, Liam Paninski
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ryota HommaDejan Zecevic
Mar 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David H GireNathan E Schoppa
Oct 1, 2013·Journal of Computational Neuroscience·Ari PakmanLiam Paninski
Oct 11, 2017·ELife·Milos RadivojevicDouglas J Bakkum

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