Functional Studies of microRNAs in Neural Stem Cells: Problems and Perspectives.

Frontiers in Neuroscience
Malin AkerblomJohan Jakobsson

Abstract

In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been implicated to play a central role in the regulation of NCSs. miRNAs are small, endogenously expressed RNAs that regulate gene expression at the post-transcriptional level. However, functional studies of miRNAs are complicated due to current technical limitations. In this review we describe recent findings about miRNAs in NSCs looking closely at miR-124, miR-9, and let-7. In addition, we highlight technical strategies used to investigate miRNA function, accentuating limitations, and potentials.

Citations

Mar 2, 2013·PloS One·Varadarajan VaishnaviArasambattu Kannan Munirajan
Mar 13, 2014·Cellular and Molecular Life Sciences : CMLS·Tran Cong TuocAnastassia Stoykova
Oct 10, 2013·Nucleic Acids Research·Daiane C F GolbertAna Tereza R de Vasconcelos
Jul 19, 2013·Journal of Neuropathology and Experimental Neurology·Xian Shuang LiuZheng Gang Zhang
Jul 28, 2012·Chemical Biology & Drug Design·Palmiro PoltronieriOscar F D'Urso
Jan 22, 2013·Proteomics·Takeshi KatsudaTakahiro Ochiya
Nov 19, 2014·ELife·Sebastian A GiustiDamian Refojo
Aug 31, 2014·Cell and Tissue Research·Laura StappertOliver Brüstle
Feb 13, 2016·Journal of Virology·Autumn J RuizStephen J Russell
Dec 22, 2012·Expert Review of Proteomics·Lianhong LiGary Guishan Xiao
Jul 11, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Amine Bahi, Jean-Luc Dreyer

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Methods Mentioned

BETA
transgenic
Electrophoresis
Chip
transfection

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