Functional study on TRPV1-mediated signalling in the mouse small intestine: involvement of tachykinin receptors

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
J G De ManP A Pelckmans

Abstract

Afferent nerves in the gut not only signal to the central nervous system but also provide a local efferent-like effect. This effect can modulate intestinal motility and secretion and is postulated to involve the transient receptor potential of the vanilloid type 1 (TRPV1). By using selective TRPV1 agonist and antagonists, we studied the efferent-like effect of afferent nerves in the isolated mouse jejunum. Mouse jejunal muscle strips were mounted in organ baths for isometric tension recordings. Jejunal strips contracted to the TRPV1 agonist capsaicin. Contractions to capsaicin showed rapid tachyphylaxis and were insensitive to tetrodotoxin, hexamethonium, atropine or L-nitroarginine. Capsaicin did not affect contractions to electrical stimulation of enteric motor nerves and carbachol. Tachykinin NK1, NK2 and NK3 receptor blockade by RP67580, nepadutant plus SR-142801 reduced contractions to capsaicin to a similar degree as contractions to substance P. The effect of the TRPV1 antagonists capsazepine, SB-366791, iodo-resiniferatoxin (iodo-RTX) and N-(4-tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC) was studied. Capsazepine inhibited contractions not only to capsaicin but also those to c...Continue Reading

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Citations

Aug 22, 2012·Rheumatology·Nora M ThouaChristopher P Denton
May 19, 2009·European Journal of Pharmacology·Benedicte Y De WinterPaul A Pelckmans
Sep 2, 2010·British Journal of Pharmacology·Werend BoesmansPieter Vanden Berghe
May 25, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S E FairbrotherH M Cox
Dec 19, 2013·British Journal of Pharmacology·Wen LuChuanyong Liu
Oct 16, 2015·Seminars in Immunopathology·Xiaoyun YuShaoyong Yu
Oct 27, 2012·European Journal of Pharmacology·Wim VermeulenBenedicte Y De Winter
Jun 6, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kenjiro MatsumotoSyunji Horie
Jun 8, 2021·Frontiers in Endocrinology·Sik Yu So, Tor C Savidge

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