Functional study on vasodilator effects of prostaglandin E2 in the newborn pig cerebral circulation

European Journal of Pharmacology
H Parfenova, C W Leffler

Abstract

Cerebral vascular reactivity to prostaglandin E2 was investigated in newborn pigs using closed cranial windows. Exogenous prostaglandin E2 is a dilator of pial arterioles that elevates cyclic AMP in cortical cerebrospinal fluid. Pial arterioles are less sensitive to prostaglandin E2 than to the prostacyclin receptor agonist iloprost, but their maximal responses to the dilator prostanoids are similar. The cerebrovascular effects of prostaglandin E2 and iloprost are not additive. Pretreatment with either iloprost or prostaglandin E2 decreases pial arteriolar responsiveness to iloprost without affecting responses to isoproterenol. The homologous desensitization of pial arterioles suggests that auto- and cross-tachyphylaxis in vascular effects of iloprost and prostaglandin E2 occur at the receptor level. Indomethacin, which selectively inhibits prostacyclin receptor-mediated responses in cerebral vascular smooth muscle, greatly reduces the vascular responses to prostaglandin E2. These results suggest that vasodilator effects of prostaglandin E2 in the newborn cerebral circulation are mediated via prostacyclin receptors coupled to adenylyl cyclase.

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Citations

Jan 3, 2001·Headache·D W DodickD J Capobianco
Oct 11, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Alie Kanu, Charles W Leffler
Apr 1, 1997·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H A PeredoE Adler-Graschinsky
Sep 1, 1997·Experimental Eye Research·M HamadaY Honda
Oct 16, 2004·Cephalalgia : an International Journal of Headache·C D'AlessioJ Schoenen
Oct 1, 1996·Stroke; a Journal of Cerebral Circulation·F BariD W Busija
Jun 20, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Xiang FangArthur A Spector
Sep 1, 2004·Experimental Biology and Medicine·Massroor PourcyrousCharles W Leffler
Dec 9, 1998·The American Journal of Physiology·X FangA A Spector

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