PMID: 1092798Jun 1, 1975Paper

Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen

The Journal of Experimental Medicine
H Cantor, E A Boyse

Abstract

Ly alloantigens coded by two unlinked genetic loci (Ly-1 and Ly-2/Ly-3) are expressed on lymphoid cells undergoing thymus-dependent differentiation. Peripheral Thy-1+ cells from C57BL/6 mice can be divided into three subclasses on the basis of differential expression of Ly-1, Ly-2, and Ly-3; about 50% express all three Ly antigens (Ly -123+), about 33% only Ly-1 (Ly-1+), and about 6-8% Ly-2 and Ly-3 (Ly-23+). Cells of the Ly-123+ subclasses are the first peripheral Thy-1+ cells to appear in ontogeny, and are reduced in the periphery shortly after adult thymectomy. In contrast, Ly-1+ and Ly-23+ subclasses appear later in the peripheral tissues than do Ly-123+ cells, and are resistant to the early effects of adult thymectomymperiheral lymphoid populations depleted of Ly-1+ cells and Ly-123+ cells (and thereby enriched for Ly-23+ cells) were incapable of developing significant helper activity to SRBC but generated substantial levels of cytotoxic activity to allogeneic target cells. The same lymphoid populations, depleted of Ly-23+ cells and Ly-123+ cells (and thereby enriched for Ly-1+ cells), produced substantial helper responses but were unable to generate appreciable levels of killer activity. These experiments imply that commi...Continue Reading

References

Jun 11, 1968·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E A BoyseL J Old

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Citations

Jan 1, 1981·Immunogenetics·S KimuraU Hämmerling
Jul 1, 1992·Cell and Tissue Research·A LiauniggJ Thalhamer
Jan 1, 1981·Journal of Cancer Research and Clinical Oncology·A C Feller, M R Parwaresch
Dec 22, 1978·Molecular and Cellular Biochemistry·H Binz, H Wigzell
Nov 1, 1985·Archives of Environmental Contamination and Toxicology·M R BleavinsM T Hsia
Dec 1, 1978·Immunogenetics·S C BoosP D Gottlieb
Jan 1, 1981·Springer Seminars in Immunopathology·D Y Leung, R S Geha
May 1, 1990·Diseases of the Colon and Rectum·A FerraraG H Ballantyne
Jan 24, 2008·Immunologic Research·K Kai McKinstrySusan L Swain
Jan 1, 1980·Cellular Immunology·D A Lawrence
Oct 1, 1985·Cellular Immunology·P S CrosierP R MacDonald
Sep 1, 1986·Cellular Immunology·S T JuM E Dorf
Jan 15, 1981·Developmental Biology·H U Lee, S J Kaufman
Feb 1, 1976·Immunochemistry·R V BlandenD C Jackson
Jan 1, 1977·Journal of Immunological Methods·J Galton, J Ivanyi
Jan 1, 1977·Journal of Immunological Methods·D T Yu, R P Gale
Jan 1, 1978·Journal of Immunological Methods·H Y Schnagl, W Boyle
Jan 1, 1978·Journal of Immunological Methods·C R Parish, I F McKenzie
Jan 1, 1980·Journal of Immunological Methods·J Kettman, M Wetzel
Jan 1, 1981·Journal of Immunological Methods·S FongJ H Vaughan
Mar 1, 1977·Mechanisms of Ageing and Development·D Segre, M Segre
Mar 1, 1984·Mechanisms of Ageing and Development·M Bruley-Rosset, I Vergnon
Jan 1, 1983·Developmental and Comparative Immunology·H M Etlinger, J M Chiller

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