Functional switch from facilitation to inhibition in the control of glutamate release by metabotropic glutamate receptors.

The Journal of Biological Chemistry
I HerreroJ Sánchez-Prieto

Abstract

We have investigated the role of metabotropic glutamate receptors linked to phosphoinositide hydrolysis in the control of glutamate release in cerebrocortical nerve terminals. The activation of these receptors with the agonist 3,5-dihydroxyphenylglycine enhanced intra-synaptosomal diacylglycerol and facilitated both the depolarization-induced increase in the cytosolic free Ca2+ concentration and the release of glutamate. However, 5 min after receptor activation, a second stimulation of the pathway with the agonist failed to produce diacylglycerol and to facilitate glutamate release. Interestingly, during the period in which the diacylglycerol response was desensitized, a strong agonist-induced inhibition of Ca2+ entry and glutamate release was observed. This change in the presynaptic effects of 3,5-dihydroxyphenylglycine is reversible since 30 min after the first stimulation, the agonist-induced inhibition of release disappeared, whereas both the production of diacylglycerol and the facilitation of glutamate release were recovered. The tonic elevation of the extracellular glutamate concentration from basal levels (0.8 microM) up to 5 microM also produced the switch from facilitation to inhibition in the receptor response. The e...Continue Reading

References

Jan 1, 1992·Neuron·Y TanabeS Nakanishi
Nov 27, 1992·Science·J D ClementsG L Westbrook
Apr 1, 1991·Journal of Neurochemistry·M V CataniaF Nicoletti
Jan 1, 1990·Annual Review of Neuroscience·D W Choi, S M Rothman
Aug 1, 1989·Neuron·L O Trussell, G D Fischbach
Mar 13, 1986·Biochemical and Biophysical Research Communications·T TamaokiF Tomita
Dec 30, 1983·Biochimica Et Biophysica Acta·B I Kanner
Jan 1, 1995·Neuropharmacology·J P Pin, R Duvoisin
May 8, 1995·The Journal of Comparative Neurology·C RomanoJ W Olney
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Jun 1, 1996·Trends in Neurosciences·J Sánchez-PrietoD G Nicholls
Dec 1, 1995·The European Journal of Neuroscience·O Manzoni, J Bockaert
Nov 29, 1996·The Journal of Biological Chemistry·I Herrero, J Sánchez-Prieto

❮ Previous
Next ❯

Citations

Aug 24, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yarí E Marín, Suzie Chen
Aug 12, 1999·European Journal of Pharmacology·J P PinF Acher
Jul 16, 2002·Pharmacology, Biochemistry, and Behavior·Alessandra ValerioPierFranco Spano
Mar 10, 2001·Trends in Pharmacological Sciences·A De BlasiF Nicoletti
Feb 28, 2002·Behavioural Brain Research·Pernilla Grillner, Nicola B Mercuri
Aug 15, 2002·Neurochemistry International·Lianne B DaleStephen S G Ferguson
Jun 12, 2001·Current Opinion in Neurobiology·S AlagarsamyP J Conn
Apr 13, 2000·The European Journal of Neuroscience·L PastorinoM Di Luca
Apr 5, 2005·The Journal of Pharmacology and Experimental Therapeutics·Stuart MaudsleyLouis M Luttrell
Feb 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dao-Zhong JinJohn Q Wang
Apr 1, 2014·Acta Pharmacologica Sinica·Weronika KrzyżanowskaJoanna Pera
Feb 7, 2012·Neurochemistry International·Filippo CaraciValeria Bruno
Dec 15, 2004·Alcoholism, Clinical and Experimental Research·Rafael GalindoDaniel D Savage
Nov 27, 2007·Neuroscience·R Padmashri, S K Sikdar
Sep 15, 2009·Toxicology Letters·Jian XuXiao-ming Shen
Sep 16, 2016·Frontiers in Pharmacology·Anna Pittaluga

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.