PMID: 15331559Aug 28, 2004Paper

Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in japanese type 2 diabetic patients

Diabetes
Tohru HamanishiKishio Nanjo

Abstract

Atherosclerosis in type 2 diabetic patients has been linked to increased oxidative stress. Glutathione peroxidase-1 (GPx-1) plays an important role in the antioxidant defense of the vascular wall. To assess the association between variants in the GPx-1 gene and atherosclerosis, we screened the gene in 184 Japanese type 2 diabetic patients and identified four polymorphisms (-602A/G, +2C/T, Ala(5)/Ala(6), and Pro198Leu). Among these polymorphisms, -602G, +2T, Ala(6), and 198Leu were in strong linkage disequilibrium with each other. The patients were divided into two groups on the basis of the codon 198 polymorphism, Pro/Pro (n = 151) and Pro/Leu (n = 33), to analyze clinical characteristics. The mean intima-media thickness (IMT) of common carotid arteries (P = 0.0028) and the prevalence of cardiovascular disease (P = 0.035) and peripheral vascular disease (P = 0.027) were significantly higher in the Pro/Leu group than in the Pro/Pro group. In vitro functional analyses indicated that the combination of polymorphisms (Ala(6)/198Leu) of the GPx-1 gene had a 40% decrease in enzyme activity, and the combination of polymorphisms (-602G/+2T) had a 25% decrease in transcriptional activity. These results suggest that functional variants i...Continue Reading

References

Dec 10, 1987·Nucleic Acids Research·K IshidaY Sukenaga
Jul 4, 1997·The Journal of Biological Chemistry·G R UpchurchJ Loscalzo
Jun 30, 2000·Biochemical and Biophysical Research Communications·S TakeshitaM Yokoyama
Dec 9, 2000·Blood Cells, Molecules & Diseases·L ForsbergR Morgenstern
Feb 24, 2001·Cellular and Molecular Life Sciences : CMLS·J R Arthur
Apr 5, 2001·American Journal of Physiology. Endocrinology and Metabolism·M P WautierJ L Wautier
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·N WeissJ Loscalzo
Mar 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Marc A ForgioneJoseph Loscalzo
Sep 13, 2002·Journal of Atherosclerosis and Thrombosis·Seiichi KobayashiMitsuhiro Yokoyama
Oct 18, 2002·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H SoneUNKNOWN JD Study Group
Oct 23, 2002·Clinical Endocrinology·Cosimo MassafraGiuseppe Buonocore

❮ Previous
Next ❯

Citations

Dec 29, 2012·European Journal of Nutrition·Gitte Ravn-HarenSusanne Bügel
Mar 21, 2009·Human Genetics·Himadri RoySeppo Yla-Herttuala
Dec 18, 2010·Bulletin of Experimental Biology and Medicine·Yu A ShuvalovaV V Kukharchuk
Jan 8, 2011·Biochemical Genetics·Sanjeev SinghB C Sarkhel
Apr 28, 2006·Current Atherosclerosis Reports·Rebecca L Pollex, Robert Hegele
Mar 5, 2011·Current Atherosclerosis Reports·Dan FarbsteinAndrew P Levy
Mar 18, 2006·Current Diabetes Reports·Frédéric FumeronGilberto Velho
Jan 1, 2009·Indian Journal of Clinical Biochemistry : IJCB·P SabithaPrakash Kamath
Mar 10, 2011·Nature Reviews. Gastroenterology & Hepatology·Shannan Tujios, Robert J Fontana
Sep 8, 2007·Antioxidants & Redox Signaling·Edith LubosDiane E Handy
Sep 12, 2008·Antioxidants & Redox Signaling·Randall S FreyAsrar B Malik
Jun 29, 2010·Antioxidants & Redox Signaling·Matthew P PepperXin Gen Lei
Nov 20, 2010·Antioxidants & Redox Signaling·Edith LubosDiane E Handy
Apr 13, 2010·Stem Cells and Development·Araceli Valle-Prieto, Paulette A Conget
Apr 9, 2010·Clinical and Experimental Pharmacology & Physiology·Eugene A Podrez
Aug 27, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrea CallegariMichael E Rosenfeld
Aug 20, 2011·Circulation Research·Frank RutschRobert Terkeltaub
Apr 27, 2011·Endocrine Journal·Takako OhyamaHiroshi Itoh
Dec 4, 2012·Nutrients·William M JohnsonJohn J Mieyal
Feb 25, 2014·International Journal of Molecular Sciences·Azahara I RupérezConcepción M Aguilera
Dec 3, 2014·Neurologia i neurochirurgia polska·Karolina SpisakAgnieszka Slowik
Nov 18, 2014·The Journal of Clinical Investigation·Judy B de Haan
Mar 7, 2012·Expert Review of Cardiovascular Therapy·Christine KoulisTerri J Allen
Jan 7, 2009·Scandinavian Journal of Clinical and Laboratory Investigation·Tine Halsen MallingØyvind Omland
Feb 11, 2016·Canadian Journal of Microbiology·Bao-gui WangHua Wei
Dec 21, 2006·Archives of Physiology and Biochemistry·Doina Popov, Maya Simionescu
Aug 21, 2010·The American Journal of the Medical Sciences·César Paz-y-MiñoMaría Eugenia Sánchez
Nov 20, 2015·Molecular Biology and Evolution·Johannes EngelkenElena Bosch

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.